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Pathogens
Special Issues
Advanced Research in Influenza Vaccines and Therapies
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Advanced Research in Influenza Vaccines and Therapies

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Vaccines and Therapeutic Developments".

Deadline for manuscript submissions: closed (31 August 2025) | Viewed by 655

Special Issue Editor

Dr. Sonia Jangra

E-Mail Website
Guest Editor
Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY, USA
Interests: vaccines; severe acute respiratory syndrome; coronavirus; influenza viruses; viral encephalitis; herpesviruses

Special Issue Information

Dear Colleagues,

Influenza continues to be a major public health challenge worldwide. Seasonal outbreaks caused by influenza A and B viruses, along with the looming threat of zoonotic strains with pandemic potential, highlight the urgent need for innovative approaches to vaccines and therapies. Moreover, despite annual vaccinations, the rate of viral transmission can still be high, suggesting inadequate or short-lived immune responses following influenza vaccination in humans. Developing effective strategies requires a deeper understanding of the interaction between influenza viruses and the host immune system to harness valuable insights for improving prevention and treatment.

This Special Issue invites contributions that explore advances in influenza vaccine development, including new platforms, adjuvants, and antiviral strategies. We are particularly interested in studies examining the role of the innate immune system, the impact of interferons on host defense, and how viral mechanisms evade these responses. Research into novel adjuvants that enhance immune responses and studies that address vaccine efficacy against evolving strains are also encouraged.

We welcome original research, reviews, and perspectives that delve into these topics and offer insights that could shape the future of influenza prevention and treatment. Let us work together to advance our understanding of influenza and move closer to solutions that can protect us against both seasonal epidemics and potential pandemics.

We look forward to your submissions!

Best regards,

Dr. Sonia Jangra
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • influenza vaccines
  • innate immunity
  • adjuvants
  • interferons
  • antiviral development
  • immune response
  • pandemic preparedness
  • vaccine innovation
  • host–virus interactions

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Published Papers (1 paper)

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30 pages, 6719 KB  
Article
Vaccinations for Expecting Mothers to Improve Pregnancy Care in Middle Tennessee
by Alphonso Harvey, Mohammad Tabatabai, Derek Wilus, Sofia Thomas, James E. K. Hildreth and Donald J. Alcendor
Pathogens 2025, 14(12), 1255; https://doi.org/10.3390/pathogens14121255 - 8 Dec 2025
Viewed by 140
Abstract
Background: During pregnancy, mothers and their infants are at increased risk for complications due to COVID-19 infection, influenza, and pertussis. At the time of writing, the previous advisory committee on immunization practices (ACIP) recommended that pregnant women receive the COVID-19 vaccine, influenza, tetanus-toxoid, [...] Read more.
Background: During pregnancy, mothers and their infants are at increased risk for complications due to COVID-19 infection, influenza, and pertussis. At the time of writing, the previous advisory committee on immunization practices (ACIP) recommended that pregnant women receive the COVID-19 vaccine, influenza, tetanus-toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine, as well as respiratory syncytial virus vaccinations during pregnancy. The COVID-19 pandemic greatly impacted routine vaccinations especially among medically underserved women in the South. The barriers to recommended vaccinations during pregnancy for medically underserved women in the South are unclear and require further investigation. The purpose of this study is to examine the attitudes, opinions, and beliefs of a multiracial pregnant cohort from diverse backgrounds in Central Tennessee about their experiences with the vaccines that are recommended during pregnancy. The vaccines included in the study are COVID-19, flu, and Tdap because RSV was not yet FDA-approved for pregnant women at the launch of this study. Methods: In this study, we focus on medically underserved women in Nashville, Tennessee, and the surrounding rural counties regarding vaccine acceptance and initiation of the COVID-19, influenza, and the Tdap vaccines. This study involved 208 pregnant people (100%) aged 18–49 years. All respondents were pregnant at the time of the study. The study consisted of a 26 question Redcap survey about participants’ beliefs, attitudes, opinions, and experiences with the COVID-19, flu, and Tdap vaccines during their pregnancy. Results: The randomly selected participants in the cohort were 40.4% White, 31.7% Black, 21.6% Hispanic, and 6.3% other race/ethnicity. The mothers in the cohort were young, with an average age of 27 years, most were married, and 52.8% had an annual household income before taxes of less than USD 35,000. Only 19.2% of the mothers in this study were very confident of the safety of the COVID-19 vaccine, compared to 32.7% for both the flu and Tdap vaccines. Overall, primary care providers were identified as the most trusted messengers for both disease and vaccine information for COVID-19, flu, and Tdap. However, only 11 participants out of 208 received all three of the ACIP recommended vaccines during their pregnancies in the study, barring the time-dependent vaccination for Tdap. The most common reasons for not receiving these vaccines involved concerns for the safety of themselves and their babies and a fear of needles. Conclusions: Education and awareness of ACIP-recommended vaccines during pregnancy needs improvement, and the support of primary care providers as the main driver of pregnancy vaccine initiation is essential. Full article
(This article belongs to the Special Issue Advanced Research in Influenza Vaccines and Therapies)
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