Orientia tsutsugamushi Infection
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (15 March 2022) | Viewed by 8915
Special Issue Editor
Special Issue Information
Dear Colleagues,
Scrub typhus is a life-threatening mite-borne infectious disease caused by Orientia tsutsugamushi, and it is transmitted primarily by the bite of the larvae of Leptotrombidium spp. mite (Acari: Trombiculiidae) infected with Orientia species.
The disease is endemic in Asian countries and the western Pacific area, an area known as the “tsutsugamushi triangle”, and causes an estimated one million cases annually.
Recently, scrub typhus has also been reported outside the usual endemic region, in areas such as South American and African countries, far from the tsutsugamushi triangle, which suggests a wider global distribution of this disease and is attracting more attention to the neglected disease. Nevertheless, the global incidence of scrub typhus is poorly defined because of the limited epidemiological data in many of the endemic countries.
After a bite from an infective mite, a characteristic necrotic inoculation lesion (an eschar) can develop, and the signs and symptoms of scrub typhus typically develop within 1–2 weeks of infection and include fever, headache, malaise, and gastrointestinal symptoms.
Coinfection with both single or different genotypes of O. tsutsugamushi and severe fever with thrombocytopenia syndrome virus (SFTSV), a new emerging tick-borne virus, could also occur in the patient.
Despite recent strides in fundamental research and the development of medical countermeasures for scrub typhus, much remains to be learned about many of these agents in order to aid our understanding of bacterial pathogenesis and for the identification and development of therapeutics and vaccines.
This Special Issue will cover a wide range of topics focusing on scrub typhus, and aims to help to enhance current knowledge of this bacteria and their respective diseases. All types of articles will be considered for publication, including short reports, primary research articles, and reviews.
We look forward to your contribution.
Prof. Dr. Keun Hwa Lee
Guest Editor
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Keywords
- Scrub typhus
- Orientia tsutsugamushi
- Mite-borne diseases
- Bacteria-host interactions
- Virulence factors
- Bacterial pathogenesis
- Transmission
- Immune activation and evasion
- Innate immunity
- Adaptive immunity
- Therapeutics
- Vaccines
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