Special Issue "Host-Pathogen Interactions and Phage Therapy"

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 2171

Special Issue Editor

Dr. Gabriel Magno de Freitas Almeida
E-Mail Website
Guest Editor
Department of Biological and Environmental Science, Nanoscience Center, University of Jyvaskyla, Jyvaskyla, Finland
Interests: host-pathogen interactions; phages; phage therapy; mucosal phages

Special Issue Information

Dear Colleagues,

Bacteriophages (phages) are intriguing organisms. Their use as therapeutic agents against bacterial infections (phage therapy) is an important medical advance of the 1920s with still relevance today. Within the context of phage therapy there is a complex network of biological interactions happening, among the three organisms involved: the phage, the targeted bacteria, and the organism infected by the bacteria.

Of the possible interactions, the first and most obvious are between the phage and its bacterial host (i), with the discovery of the CRISPR system as a recent example of how these processes can be explored for biological research. Then there are the interactions between the bacteria and the organism it infects (ii), such as virulence factors and immune evasion. The phage can interact with the host infected by the bacteria (iii), as exemplified by the synergism between phages and the mammalian immune system. It is known that tripartite interactions between the phage, the bacteria it targets, and the host infected by the bacteria can happen (iv), as in the bacteriophage adherence to mucus model. Finally, there are more complex interactions in which other microbes are involved (v), with microbiome modulation or inside biofilm communities. The study of these host–pathogen processes is not only interesting from a basic research point of view, but also has immense value for biotechnology and therapeutics.

In this Special Issue we aim to address the relevance of host–pathogen interactions for experimental and applied phage therapy. We welcome the submission of research material focused on any of the five different biological interaction points mentioned above, hoping that these will result in better understanding of phage-therapy-related biological interactions and open new doors to improve phage use and innovate in general phage research.

Dr. Gabriel Magno de Freitas Almeida
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • host–pathogen interactions
  • phages
  • phage therapy
  • antimicrobial resistance
  • bacterial diseases
  • virulence factors
  • antibiotics
  • microbial communities
  • biological interactions

Published Papers (1 paper)

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Sepsis, Phages, and COVID-19
Pathogens 2020, 9(10), 844; https://doi.org/10.3390/pathogens9100844 - 15 Oct 2020
Cited by 5 | Viewed by 1820
Phage therapy has emerged as a potential novel treatment of sepsis for which no decisive progress has been achieved thus far. Obviously, phages can help eradicate local bacterial infection and bacteremia that may occur in a syndrome. For example, phages may be helpful [...] Read more.
Phage therapy has emerged as a potential novel treatment of sepsis for which no decisive progress has been achieved thus far. Obviously, phages can help eradicate local bacterial infection and bacteremia that may occur in a syndrome. For example, phages may be helpful in correcting excessive inflammatory responses and aberrant immunity that occur in sepsis. Data from animal studies strongly suggest that phages may indeed be an efficient means of therapy for experimentally induced sepsis. In recent years, a number of reports have appeared describing the successful treatment of patients with sepsis. Moreover, novel data on the anti-viral potential of phages may be interpreted as suggesting that phages could be used as an adjunct therapy in severe COVID-19. Thus, clinical trials assessing the value of phage therapy in sepsis, including viral sepsis, are urgently needed. Full article
(This article belongs to the Special Issue Host-Pathogen Interactions and Phage Therapy)
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