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Journals
Pathogens
Special Issues
Current Research on Enterovirus Infection
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Current Research on Enterovirus Infection

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1871

Special Issue Editors

Prof. Dr. Ming-Liang He

E-Mail Website
Guest Editor
Department of Biomedical Sciences, City University of Hong Kong, Hong Kong
Interests: enterovirus; anticancer; antiviral; signaling transduction; endoplasmic reticulum (ER) stress; innate immune response
Prof. Dr. Honglin Luo

E-Mail Website
Guest Editor
Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
Interests: enteroviruses; viral pathogenesis; virus-host interaction; oncolytic viruses
Prof. Dr. Zhaohua Zhong

E-Mail Website
Guest Editor
Department of Microbiology, Harbin Medical University, Harbin 150081, China
Interests: pathogenesis; virus-host interaction; antiviral intervention

Special Issue Information

Dear Colleagues,

Enteroviruses (EVs) are common human and animal pathogens which contain a positive-sense (+) single-stranded RNA viral genome. EVs infect millions of people annually, and result in a variety of symptoms from wild respiratory illness to hand, foot and mouth disease (HFMD); myocarditis; aseptic meningitis; acute hemorrhagic conjunctivitis; and severe neurological disorders such as neonatal sepsis-like diseases, acute flaccid paralysis and even quick disease.   

This Special Issue will focus on the current advances on EV research, including host–virus interaction, virus detection, mechanisms of viral pathogenesis, factors involved in infectivity and virulence, signal transduction, viral immunology, and drug development. Comprehensive review and research articles are welcome.

Prof. Dr. Ming-Liang He
Prof. Dr. Honglin Luo
Prof. Dr. Zhaohua Zhong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • enteroviruses
  • host–virus interaction
  • viral pathogenesis
  • virus detection
  • viral infectivity
  • viral virulence
  • viral immunology
  • antiviral drugs

Published Papers (1 paper)

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Research

13 pages, 7689 KiB  
Article
Molecular Characteristics and Genetic Evolution of Echovirus 33 in Mainland of China
by Wenhui Wang, Huan Fan, Shuaifeng Zhou, Shikang Li, Alitengsaier NIGEDELI, Yong Zhang, Qiang Sun, Yun He, Qin Guo, Xiaoyi Wang, Huanhuan Lu, Jinbo Xiao, Hehe Zhao, Zhenzhi Han, Tianjiao Ji, Le Zhang and Dongmei Yan
Pathogens 2022, 11(11), 1379; https://doi.org/10.3390/pathogens11111379 - 18 Nov 2022
Viewed by 1506
Abstract
Echovirus, a member of the Enterovirus B (EV-B) family, has led to numerous outbreaks and pandemics, causing a broad spectrum of diseases. Based on the national hand, foot, and mouth disease (HFMD) surveillance system, seven strains of echovirus 33 (E33) were [...] Read more.
Echovirus, a member of the Enterovirus B (EV-B) family, has led to numerous outbreaks and pandemics, causing a broad spectrum of diseases. Based on the national hand, foot, and mouth disease (HFMD) surveillance system, seven strains of echovirus 33 (E33) were isolated from Mainland of China between 2010 and 2018. The whole genomes of these strains were isolated and sequenced, and phylogenetic trees were constructed based on the gene sequences in different regions of the EV-B prototype strains. It was found that E33 may be recombined in the P2 and P3 regions. Five genotypes (A–E) were defined based on the entire VP1 region of E33, of which the C gene subtype was the dominant gene subtype at present. Recombinant analysis showed that genotype C strains likely recombined with EV-B80, EV-B85, E13, and CVA9 in the P2 and P3 regions, while genotype E had the possibility of recombination with CVB3, E3, E6, and E4. Results of Bayesian analysis indicated that E33 may have appeared around 1955 (95% confidence interval: 1945–1959), with a high evolutionary rate of 1.11 × 10−2 substitution/site/year (95% highest posterior density (HPD): 8.17 × 10−3 to 1.4 × 10−2 substitution/site/year). According to spatial transmission route analysis, two significant transmission routes were identified: from Australia to India and from Oman to Thailand, which the E33 strain in Mainland of China likely introduced from Mexico and India. In conclusion, our study fills the gaps in the evolutionary analysis of E33 and can provide important data for enterovirus surveillance. Full article
(This article belongs to the Special Issue Current Research on Enterovirus Infection)
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