Molecular Characteristics and Genetic Evolution of Echovirus 33 in Mainland of China
Abstract
:1. Introduction
2. Materials and Methods
2.1. Viral Isolation and Molecular Typing
2.2. Whole-Genome Sequencing of E33
2.3. Dataset Establishment
2.4. Recombination Analysis of the Seven Isolated E33 Strains
2.5. Phylogenetic Analysis of E33
3. Results
3.1. Five Genotypes Were Reclassified Based on the VP1 Sequences
3.2. Two Different Recombination Patterns Were Found between Different Genotypes
3.3. Special Recombination Pattern of Genotype C
3.4. High Nucleotide Substitution Rate in the VP1 Region of E33
3.5. Global Geographic Transmission Paths of E33
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Wang, W.; Fan, H.; Zhou, S.; Li, S.; NIGEDELI, A.; Zhang, Y.; Sun, Q.; He, Y.; Guo, Q.; Wang, X.; et al. Molecular Characteristics and Genetic Evolution of Echovirus 33 in Mainland of China. Pathogens 2022, 11, 1379. https://doi.org/10.3390/pathogens11111379
Wang W, Fan H, Zhou S, Li S, NIGEDELI A, Zhang Y, Sun Q, He Y, Guo Q, Wang X, et al. Molecular Characteristics and Genetic Evolution of Echovirus 33 in Mainland of China. Pathogens. 2022; 11(11):1379. https://doi.org/10.3390/pathogens11111379
Chicago/Turabian StyleWang, Wenhui, Huan Fan, Shuaifeng Zhou, Shikang Li, Alitengsaier NIGEDELI, Yong Zhang, Qiang Sun, Yun He, Qin Guo, Xiaoyi Wang, and et al. 2022. "Molecular Characteristics and Genetic Evolution of Echovirus 33 in Mainland of China" Pathogens 11, no. 11: 1379. https://doi.org/10.3390/pathogens11111379