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Pathogens
Special Issues
Oncoviruses and Their Potential Role in Breast Cancer
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Oncoviruses and Their Potential Role in Breast Cancer

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 4667

Special Issue Editors

Prof. Dr. Ala-Eddin Al Moustafa

E-Mail Website1 Website2
Guest Editor
Affiliation 1: Oncology Department, McGill University, Montreal, Canada Affiliation 2: College of Medicine, Qatar University, Doha, Qatar
Interests: Oncoviruses; gene cooperation; drug discovery; drug delivery; cancer therapeutics
Special Issues, Collections and Topics in MDPI journals
Dr. Semir Vranic

E-Mail Website
Guest Editor
Associate Professor of Pathology, College of Medicine, Qatar University, Doha, Qatar
Interests: pathology; breast cancer; molecular pathology; biomarkers
Dr. Hamda Al-Thawadi

E-Mail Website
Guest Editor
Associate Professor, College of Medicine, Qatar University, Doha, Qatar
Interests: oncoviruses; breast cancer; gene mutation
Dr. Ishita Gupta

E-Mail Website
Guest Editor
Laboratory of Immune Biological Therapy, Sidra Medicine, Doha, Qatar
Interests: cancer progression; molecular biology; genetics; oncoviruses

Special Issue Information

Dear Colleagues,

Viruses are one of the main predisposing factors of oncogenesis. Since the 1930s, viruses have been associated with tumors, leading to the discovery of several oncoviruses to date. Both DNA and RNA viruses are reported to be involved in the onset and progression of various human cancers; nevertheless, the role of oncoviruses in the initiation and progression of breast cancer has been a controversial topic. Today, numerous oncoviruses have been identified in various types of cancers, including breast cancer; those viruses include Epstein–Barr virus (EBV), human papillomavirus (HPV), hepatitis B virus (HBV), human herpes virus-8 (HHV-8), human T lymphotrophic virus type 1 (HTLV-1) and hepatitis C virus (HCV). Viral infection is not often sufficient to induce cellular transformation, requiring the presence of other factors, including immunosuppression, genetic predisposition, and exposure to carcinogens, in addition to the possibility of viral/bacterial coinfection.

Therefore, novel therapeutic approaches including anti-latent viral drugs, immunological therapies as well as oncolytic viruses are known to be highly advanced as compared to traditional chemo and radiotherapies. For this Special Issue, we invite authors to contribute original research, clinical trials, and reviews focused on the role of oncoviruses in human carcinogenesis, specifically breast cancer.

Potential topics include, but are not limited to, the following:

  • In vitro and in vivo studies that aim to identify underlying mechanisms underpinning virus-induced breast cancer;
  • Viruses as candidate prognostic biomarkers;
  • Multiomic analysis of human breast tumors caused by viruses;
  • Modulation and evasion of the immune system related to oncoviruses;
  • Drug discovery of oncovirus-related carcinogenesis;
  • Bioinformatics approaches to characterize oncoviruses in breast cancers.

Prof. Dr. Ala-Eddin Al Moustafa
Dr. Semir Vranic
Dr. Hamda Al-Thawadi
Dr. Ishita Gupta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • breast cancer
  • oncoviruses
  • therapeutics
  • vaccines
  • breast cancer multiomics

Published Papers (2 papers)

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Research

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9 pages, 260 KiB  
Article
Prevalence of Polyomaviruses and Herpesviruses in Moroccan Breast Cancer
by Amina Gihbid, Amal El Amrani, Fatima Zahra Mouh, Tarik Gheit, Mustapha Benhessou, Mariam Amrani, Sandrine McKay-Chopin, Selma Mohamed Brahim, Souha Sahraoui, Abdelouaheb Bennani, Mohammed El Mzibri and Meriem Khyatti
Pathogens 2023, 12(5), 640; https://doi.org/10.3390/pathogens12050640 - 25 Apr 2023
Cited by 1 | Viewed by 1281
Abstract
Breast cancer (BC) is the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide, accounting for 24.5% of total new cancer cases and 15.5% of total cancer deaths. Similarly, BC is the most common cancer among Moroccan women, [...] Read more.
Breast cancer (BC) is the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide, accounting for 24.5% of total new cancer cases and 15.5% of total cancer deaths. Similarly, BC is the most common cancer among Moroccan women, comprising a noteworthy percentage of 40% of all cancers in women. Globally, 15% of cancers are attributable to infections; among them, viruses play a significant role. The present study aimed to explore the presence of a wide range of viral DNA in samples recovered from 76 Moroccan patients with BC and 12 controls using Luminex technology. The explored viruses were as follows: 10 polyomaviruses (PyVs): BKV, KIV, JCV, MCV, WUV, TSV, HPyV6, HPyV7, HPyV9, and SV40; and 5 Herpesviruses (HHVs): CMV, EBV1, EBV2, HSV1, and HSV2. Our results revealed the presence of PyVs DNA in both control (16.7%) and BC tissues (18.4%). Nonetheless, HHV DNA was detected exclusively in BC tissues (23.7%), with a predominance of Epstein–Barr virus (EBV) (21%). In conclusion, our study highlights the presence of EBV in human BC tissues, which may play an important role in its development and/or progression. Further investigations are needed to confirm the presence/co-presence of these viruses in BC. Full article
(This article belongs to the Special Issue Oncoviruses and Their Potential Role in Breast Cancer)

Review

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29 pages, 500 KiB  
Review
Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions
by Queenie Fernandes, Soumaya Allouch, Ishita Gupta, Ibrahim Elmakaty, Khaled E. Elzawawi, Ahmed Amarah, Hamda Al-Thawadi, Halema Al-Farsi, Semir Vranic and Ala-Eddin Al Moustafa
Pathogens 2022, 11(11), 1380; https://doi.org/10.3390/pathogens11111380 - 19 Nov 2022
Cited by 6 | Viewed by 2779
Abstract
The human papillomavirus (HPV) is a non-enveloped double-stranded DNA virus capable of infecting skin and mucosa epithelial cells. Commonly, HPV infection is associated with sexually transmitted diseases and is considered the leading cause of cervical cancer and other carcinomas of the anogenital tract. [...] Read more.
The human papillomavirus (HPV) is a non-enveloped double-stranded DNA virus capable of infecting skin and mucosa epithelial cells. Commonly, HPV infection is associated with sexually transmitted diseases and is considered the leading cause of cervical cancer and other carcinomas of the anogenital tract. However, several studies reported their involvement in cancers of non-sexual regions, including colorectal, head and neck, and breast cancers. There are several studies from the Middle East and North Africa (MENA) regions on the potential association between high-risk HPVs and cancer; nevertheless, there are limited studies that address the significance of HPV vaccination as a potential guard against these cancers. In the current review, we present a comprehensive description of the current HPV-associated cancers prevalence rates in the MENA region, demonstrating their steady increase with time, especially in African regions. Moreover, we discuss the potential impact of vaccination against HPV infections and its outcome on human health in this region. Full article
(This article belongs to the Special Issue Oncoviruses and Their Potential Role in Breast Cancer)
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