Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions
Abstract
:1. Introduction
2. High-Risk HPVs in Cervical Cancer
2.1. In GCC Countries and Yemen
2.2. In Levant Countries
2.3. In Maghreb Countries
2.4. In Other Countries of the MENA Region and Turkey
3. High-Risk HPVs in Head and Neck Cancer
3.1. In GCC Countries and Yemen
3.2. In Levant Countries
3.3. In Maghreb Countries
3.4. In Other Countries of the MENA Region and Turkey
4. High-Risk HPVs in Colorectal Cancer
4.1. In GCC Countries and Yemen
4.2. In Levant Countries
4.3. In Maghreb Countries
4.4. In Other Countries of the MENA Region and Turkey
5. High-Risk HPVs in Breast Cancer
5.1. In GCC Countries and Yemen
5.2. In Levant Countries
5.3. In Maghreb Countries
5.4. In Other Countries of the MENA Region and Turkey
6. Prevention Strategies of HPVs Infection
6.1. CervarixTM
6.2. Gardasil®
6.3. Gardasil®9
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Population (Year) | Country/Region | Cases (n) | Type of Cancer | HPV Prevalence (%) | Reference |
---|---|---|---|---|---|
2020 | MENA region | 6104 | Cervical cancer | 81 | [62] |
Abnormal cervical cytology | 54 | ||||
General population | 16 | ||||
2020 | Maghreb countries | 1001 | Cervical cancer | 88 | [62] |
2020 | Iran | 1138 | Cervical cancer | 73 | [62] |
2020 | Northeast Africa | 302 | Abnormal cervical cytology | 94 | [62] |
2020 | Northeast Africa | 441 | Abnormal cervical cytology | 31 | [62] |
Population (Year) | Cases (n) | Cancer | HPV Prevalence (%) | Detection Method | Reference |
---|---|---|---|---|---|
Iran (2022) | 62 | HNSCC | 12.9% | PCR | [128] |
Iran (2021) | 108 | HNSCC | 23.1% | Nested-PCR and overlapping nested-PCR | [129] |
Iran (2021) | 46 | HNSCC | 6.5% | PCR | [130] |
Turkey (2021) | 106 | HNSCC | 24.5% | CFX96 real-time PCR | [131] |
Turkey (2020) | 44 | Laryngeal carcinoma | 2.2% | Multiplex real-time PCR | [132] |
Tunisia (2020) | 70 | Laryngeal carcinoma | 55.71% | ISH | [133] |
Jordan (2020) | 61 | HNSCC | 31% | Real-time PCR | [134] |
Jordan (2020) | 52 | LSCC | 15.4% | PCR | [135] |
Syria (2020) | 80 | HNC | 43.7% | PCR and IHC | [136] |
Egypt (2020) | 92 | HNSCC | 3.3% | HPV direct flow CHIP system and PCR | [137] |
Saudi Arabia (2020) | 44 | OTSCC | 23% | PCR | [138] |
Saudi Arabia (2019) | 285 | OPSCC and HNSCC | 3.5% (HNSCC) 21% (OPSCC) | HPV linear-array and RealLine HPV-HCR | [139] |
Saudi Arabia (2019) | 45 | OCSCC | 0% | ISH | [140] |
Turkey (2019) | 53 | ESCC | 2% | PCR (Aptima Panther system) | [141] |
Turkey (2019) | 90 | Laryngeal carcinoma | 12.2% | PCR | [142] |
Turkey (2019) | 52 (Only 40 samples amplified by PCR) | LSCC | 2.5% | PCR | [143] |
Turkey (2018) | 93 (11 normal laryngeal mucosa and 82 laryngeal cancer) | Laryngeal carcinoma | 0% (normal and cancer) | Chromogenic ISH | [144] |
Turkey (2018) | 82 | NPC | 1.2% | HPV ISH | [145] |
Egypt (2019) | 99 | OPSCC, lip and tongue SCC (32) | 28% (OPSSC) 37% (lip and tongue SCC) | DNA ISH | [146] |
Egypt (2018) | 126 (70 benign and 56 cases) | LSCC | 0% (benign) 3.6% (cases) | PCR | [147] |
Lebanon (2018) | 30 | OPSCC | 27% | PCR | [148] |
Iran (2017) | 156 | HNSCC | 3.2% | PCR | [149] |
Iran (2017) | 50 | LSCC | 28% | PCR | [150] |
Egypt (2017) | 50 | LSCC | 18% | IHC | [151] |
Jordan (2017) | 16 | LSCC and OSCC | 15% (pooled prevalence6% (LSCC) 20% (OSCC) | Nested PCR | [152] |
Turkey (2017) | 28 | LSCC | 26% | Genotyping assay | [153] |
Algeria (2016) | 10 | HNC | 0% | InnoLiPA HPV genotyping test | [105] |
Iran (2016) | 103 | ESCC | 10.7% | PCR and InnoLiPA | [154] |
Iran (2016) | 96 (45 controls and 51 cases) | ESCC | 44.4% (controls) 31.4% (cases) | Real-time PCR | [155] |
Iran (2016) | 40 (37 benign and 3 cases) | Sinonasal inverted papilloma | 18.9% (benign) 100% (cases) | PCR | [156] |
Turkey (2015) | 52 | Esophageal carcinoma | 9.6% | Real-time PCR | [157] |
Iran (2014) | 30 | ESCC | 0% | PCR | [158] |
Iran (2014) | 82 (22 normal and 60 cases) | Laryngeal carcinoma | 0% | PCR | [159] |
Yemen (2014) | 60 | OSCC | 0% | Taqman quantitative PCR | [160] |
Iran (2013) | 177 | ESCC | 27.7% | PCR | [161] |
Iran (2012) | 14 | HNSCC | 43% | PCR | [162] |
Iran (2012) | 177 | ESCC | 21.6% | PCR | [163] |
Iran (2011) | 93 | ESCC | 8.6% | PCR and InnoLiPA | [164] |
UAE (2011) | 45 | OSCC | 73.3% | PCR | [165] |
Iran (2009) | 22 | OSCC | 41% | PCR | [166] |
Turkey (2009) | 65 | Laryngeal and hypopharyngeal carcinoma | 41.5% | PCR | [167] |
Turkey (2008) | 50 | Laryngeal carcinoma | 14% | PCR and hybrid capture method | [168] |
Turkey (2005) | 26 | HNSCC | 15% | Chromogenic ISH | [169] |
Egypt (2005) | 50 | Esophageal carcinoma | 54% | PCR and InnoLiPA | [170] |
Country | Cases (n) | HPV Prevalence (%) | Detection Method | Reference |
---|---|---|---|---|
Iran | 38 | 13 (34%) | Nested and semi-quantitative PCR | [178] |
74 | 9 (12%) | Nested PCR | [179] | |
72 | 60 (83%) | MY/GP nested PCR, P5+/GP6+ auto-nested PCR and direct DNA sequencing | [180] | |
84 | 19 (23%) | q-RTPCR | [181] | |
66 | 3 (4%) | q-RTPCR | [182] | |
140 | 6 (4%) | PCR | [183] | |
80 | 5 (4%) | Nested PCR and sequencing methods | [184] | |
100 | 1 (1%) | PCR | [185] | |
50 | 0 (0%) | PCR | [186] | |
Turkey | 56 | 46 (82%) | PCR and Southern blot hybridization | [187] |
53 | 43 (81%) | PCR and Southern blot hybridization | [188] | |
67 | 39 (76%) & 30 (59%) | PCR and Southern blot hybridization/direct DNA sequencing | [189] | |
72 | 5 (7%) | HPV ISH | [190] | |
168 | 0 (0%) | Nested PCR | [191] | |
Syria | 78 | 42 (54%) | Multiplex PCR and HPV probe array/reverse line-blot assay | [53] |
102 | 38 (37%) | PCR and IHC | [192] | |
Iraq | 62 | (44%) | CISH | [193] |
Lebanon | 94 | 60 (64%) | PCR and IHC | [17] |
Israel | 106 | 0 (0%) | GP5+/GP6+ PCR reverse line blot method and SPF10 INNO-LiPA method | [194] |
Saudi | 132 | 2 (1.5%) | HC2 assay | [195] |
83 | 0 (0%) | PCR and IHC | [196] | |
Egypt | 40 | 4 (15%) | Real-time PCR | [197] |
Country | Sample Type | Cases (n) | HPVs+ (%) | Reference |
---|---|---|---|---|
Algeria | Paraffin | 123 | 17.9 | [206] |
Egypt | Frozen | 20 | 20 | [207] |
Iran | Paraffin/Frozen | 1539 | 23.6 (6.7–40.5) | [208] |
Paraffin | 59 | 11.8 | [209] | |
Paraffin | 72 | 5.55 | [210] | |
Paraffin | 98 | 8.2 | [181] | |
Paraffin | 150 | 0 | [211] | |
Iraq | Fresh | 150 | 30.67 | [212] |
Jordan | Paraffin | 100 | 21 | [213] |
Lebanon | Paraffin | 102 | 65 | [214] |
Morocco | Frozen | 76 | 5 | [215] |
Qatar | Fresh | 33 | 12.12 | [216] |
Paraffin | 74 | 65 | [217] | |
Syria | Paraffin | 113 | 61.06 | [218] |
Tunisia | Paraffin | 123 | 0 | [219] |
Egypt | Paraffin | 40 | 17 | [220] |
WBC | 40 | 40 | ||
Fresh | 40 | 50 | ||
Egypt | Paraffin | 135 | Non-inflammatory: 76 | [221] |
Inflammatory: 66 | ||||
Turkey | Frozen | 50 | 74 | [222] |
Paraffin | 45 | 29.6–44.4 | [223] |
Bivalent Vaccine | Quadrivalent Vaccine | Nonavalent Vaccine | |
---|---|---|---|
Brand Name | Cervarix | Gardasil | Gardasil-9 |
HPV Subtypes | HPV-16, -18 | HPV-6, -11, -16, and -18 | HPV-6, -11, -16, -18, -31, -33, -45, -52, and -58 |
Adjuvant System | AS04 adjuvant system in sodium chloride, sodium dihydrogen phosphate dihydrate | Amorphous aluminum hydroxyphosphate sulfate | Amorphous aluminum hydroxyphosphate sulfate |
Expression system | Baculovirus-insect cell | Yeast | Yeast |
Scheduled dose | 0, 1, and 6 months | 0, 2, and 6 months | 0, 2, and 6 months |
Recommended dose | 20/20 μg | 20/40/40/20 μg | 30/40/60/40/20/20/20/20/20 μg |
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Fernandes, Q.; Allouch, S.; Gupta, I.; Elmakaty, I.; Elzawawi, K.E.; Amarah, A.; Al-Thawadi, H.; Al-Farsi, H.; Vranic, S.; Al Moustafa, A.-E. Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions. Pathogens 2022, 11, 1380. https://doi.org/10.3390/pathogens11111380
Fernandes Q, Allouch S, Gupta I, Elmakaty I, Elzawawi KE, Amarah A, Al-Thawadi H, Al-Farsi H, Vranic S, Al Moustafa A-E. Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions. Pathogens. 2022; 11(11):1380. https://doi.org/10.3390/pathogens11111380
Chicago/Turabian StyleFernandes, Queenie, Soumaya Allouch, Ishita Gupta, Ibrahim Elmakaty, Khaled E. Elzawawi, Ahmed Amarah, Hamda Al-Thawadi, Halema Al-Farsi, Semir Vranic, and Ala-Eddin Al Moustafa. 2022. "Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions" Pathogens 11, no. 11: 1380. https://doi.org/10.3390/pathogens11111380
APA StyleFernandes, Q., Allouch, S., Gupta, I., Elmakaty, I., Elzawawi, K. E., Amarah, A., Al-Thawadi, H., Al-Farsi, H., Vranic, S., & Al Moustafa, A.-E. (2022). Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions. Pathogens, 11(11), 1380. https://doi.org/10.3390/pathogens11111380