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Pathogens
Special Issues
Biomarkers in Infectious Diseases
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Biomarkers in Infectious Diseases

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 30 March 2026 | Viewed by 1167

Special Issue Editor

Dr. Yiu Wing (Jason) Kam

E-Mail Website
Guest Editor
Division of Natural and Applied Sciences, Duke Kunshan University, Kunshan 215316, China
Interests: adaptive immune response; IgG class switching; epitope identification; virus-host interaction; biomarker identification; immunotherapy development; epitope-specific antibodies; vaccine candidates; infectious diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Infectious diseases pose a significant public health challenge, thus enhancing our need for swift and precise diagnostic protocols that enable the administration of effective treatments. Biomarkers facilitate the early detection of infectious diseases and provide guidance regarding their treatment and prognostic assessment. Biomarkers could therefore enhance the identification, management, and application of therapeutic strategies for infectious illnesses. To realize their potential, we must address the challenges associated with biomarkers by performing rigorous research, enhancing innovation, and embedding these innovations into routine clinical practice. 

This Special Issue aims to provide a platform for the dissemination of research regarding the application of biomarkers and their prospective contributions to the field. We aim to assemble a collection of research papers, insightful reviews, and pioneering studies that investigate the evolving role of biomarkers in comprehending and treating infectious diseases. 

We therefore invite you to submit recent research, perceptive reviews, or comprehensive investigations that focus on the investigation of novel biomarkers, cutting-edge diagnostic methodologies, and the impact of biomarkers on infectious disease science. The scope of this Special Issue includes the decoding of molecular signatures, the enhancement of diagnostic algorithms, and the invention of novel prognostic systems.

Dr. Yiu Wing (Jason) Kam
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infectious diseases
  • immune response
  • diagnostic biomarker
  • prognostic biomarker
  • pathogen-specific biomarker
  • biomarker validation
  • biomarker-guided therapy

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

14 pages, 554 KB  
Article
Systemic Inflammatory Indices (SII and SIRI) in 30-Day Mortality Risk Stratification for Community-Acquired Pneumonia: A Study Alongside CURB-65 and PSI
by Orkun Eray Terzi, Gülgün Çetintaş Afşar, Nazlı Çetin and Seyhan Dülger
Pathogens 2025, 14(12), 1235; https://doi.org/10.3390/pathogens14121235 - 3 Dec 2025
Viewed by 690
Abstract
Community-acquired pneumonia (CAP) remains a leading cause of morbidity and mortality worldwide, underscoring the need for accessible and cost-effective biomarkers to support early risk assessment. This retrospective study investigated the prognostic performance of two systemic inflammatory indices—the Systemic Immune-Inflammation Index (SII) and the [...] Read more.
Community-acquired pneumonia (CAP) remains a leading cause of morbidity and mortality worldwide, underscoring the need for accessible and cost-effective biomarkers to support early risk assessment. This retrospective study investigated the prognostic performance of two systemic inflammatory indices—the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI)—in 240 adults hospitalized with CAP between January and December 2024. The primary outcome was 30-day all-cause mortality. Logistic regression and receiver operating characteristic (ROC) analyses were applied to compare these indices with established severity scores, CURB-65 and the Pneumonia Severity Index (PSI). Thirty-day mortality occurred in 15.4% of patients. Non-survivors exhibited significantly higher SII values (p = 0.043) and a trend toward increased SIRI levels (p = 0.072). Both indices showed weak but statistically significant positive correlations with conventional inflammatory markers such as C-reactive protein and procalcitonin. While CURB-65 and PSI retained superior discriminative ability, SII and SIRI provided only modest prognostic information and did not significantly improve mortality prediction beyond these scores. These findings indicate that simple, hematology-based indices reflecting systemic inflammation may offer limited but potentially clinically relevant adjunctive information when integrated with traditional clinical scoring systems. Full article
(This article belongs to the Special Issue Biomarkers in Infectious Diseases)
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