Bone Biomechanics: Diseases, Treatment and Rehabilitation II

A special issue of Osteology (ISSN 2673-4036).

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1972

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Guest Editor
Department of Physical Education and Sports (EPS), University of Reims Champagne-Ardenne, 51100 Reims, France
Interests: biomechanics of health disease and rehabilitation; industry engineering for medicine and high-level sport
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Special Issue Information

Dear Colleagues,

Biomechanics is a discipline concerned with the application of the tools, methods, and formalisms of mechanics and automation aiming to study human movement. By dealing specifically with the biological aspects of humans in motion, this discipline concerns the kinematic, mechanical, and control aspects of posture and movement. This discipline promotes a multifactorial approach that allows for an infinity of possible solutions to be envisaged for each motion and posture, thus contributing to the understanding of human mechanics. Biomechanics permits the estimation of human capacities by using the principles of mathematics, functional anatomy, and mechanics to explore and understand biological problems. The advantage of this discipline is that it requires understanding the musculoskeletal system to improve its potential. Taking into account personal factors offers the possibility to choose a particular solution allowing for the optimization of human mechanics. The aim of this Special Issue is to quantify the methodological advances in osteology in clinical situations. This Special Issue is concerned with studying and analyzing biomechanical contributions; bone diseases, including fractures; the interactions between bone and other organ systems, including cartilage, muscle, neurons, joints, and the spine; bone biomaterials; and prostheses.

Prof. Dr. Redha Taiar
Guest Editor

Manuscript Submission Information

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Published Papers (1 paper)

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Research

14 pages, 301 KiB  
Article
The Influence of Anti-Citrullinated Polypeptide Antibodies on Bone Mineral Density Decrease and Incident Major Osteoporotic Fractures in Patients with Rheumatoid Arthritis: A Retrospective Case-Control Study
by Ichiro Yoshii, Tatsumi Chijiwa and Naoya Sawada
Osteology 2023, 3(2), 47-60; https://doi.org/10.3390/osteology3020006 - 6 Apr 2023
Viewed by 1395
Abstract
Background: Effects of anti-citrullinated polypeptide antibodies (ACPA) on the bone mineral density (BMD) reduction and incidence of major osteoporotic fractures (MOF) in patients with rheumatoid arthritis (RA) were evaluated using a retrospective longitudinal case-control study. Methods: Patients with RA who were examined using [...] Read more.
Background: Effects of anti-citrullinated polypeptide antibodies (ACPA) on the bone mineral density (BMD) reduction and incidence of major osteoporotic fractures (MOF) in patients with rheumatoid arthritis (RA) were evaluated using a retrospective longitudinal case-control study. Methods: Patients with RA who were examined using dual-energy X-ray absorptiometry and simultaneously treated for more than 5 years were recruited. BMD absolute value and Z-scores at initial measurements (baseline) and changes of these values from baseline were assessed, and associations between BMD and candidate risk factors including ACPA positivity and serum titer levels were statistically evaluated. Additional statistical evaluations of ACPA positivity in regard to the incidence of MOF were tested. Results: A total of 222 patients were included. Higher ACPA titers correlated significantly with lower BMD and Z-scores at baseline using a multivariate model (p < 0.05). ACPA positivity correlated significantly with lower values and an annual decrease in the Z-score in total hip at follow-up using a univariate model (p < 0.05), whereas no significant correlation was found using a multivariate model. Z-scores in the ACPA-positive group were significantly lower than those of the ACPA-negative group (p < 0.05). However, ACPA-positivity demonstrated no higher risk for incident MOF. Conclusions: The presence of ACPA is a potential risk of BMD loss however weak. Full article
(This article belongs to the Special Issue Bone Biomechanics: Diseases, Treatment and Rehabilitation II)
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