The Role of Dietary Magnesium in Heart Disease

Dear Colleagues,

Cardiovascular Deaths, including ischaemic heart disease and stroke, account for the top two global causes of death, and they rose by 35% and 26% between 1990 and 2010, respectively. Heart disease continues to rise as the leading cause of human death worldwide. Magnesium is an essential dietary element for human health, and its dietary intake has been measured as “low” or “deficient” in most of the world for several decades. It is the fourth most abundant cation in the human body and is involved in several essential physiological, biochemical, and cellular processes regulating cardiovascular function. In the heart, magnesium plays a key role in modulating neuronal excitation, intracardiac conduction, and myocardial contraction by regulating a number of ion transporters, including potassium and calcium channels. Magnesium also has a role in regulating vascular tone, atherogenesis and thrombosis, vascular calcification, and proliferation and migration of endothelial and vascular smooth muscle cells. As such, magnesium has a major influence on the pathogenesis of cardiovascular disease. Current evidence from epidemiological studies shows that a higher Mg intake, either dietary or via supplementation, is associated with protection against major CV risk factors, including MetS, T2D, and hypertension/BP, as well as against stroke and total CVDs.

The purpose of this Special Issue, “The Role of Dietary Magnesium in Heart Disease,” is to provide cutting-edge research, especially original (epidemiological, clinical, and experimental) and review articles (including systematic reviews and meta-analyses), regarding the relation between dietary magnesium intake and heart failure, coronary heart disease and cardiovascular disease and/or risk factors in different populations.

Dr. Andrea Rosanoff
Guest Editor

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• dietary magnesium
• heart disease
• heart failure
• coronary heart disease
• cardiovascular
• metabolic syndrome
• mortality
• CVD risk factors