Application of Controlled Release and Targeting Strategies to Nutraceutical Ingredients and Products

A special issue of Nutraceuticals (ISSN 1661-3821).

Deadline for manuscript submissions: closed (9 October 2022) | Viewed by 3858

Special Issue Editor

Special Issue Information

Dear Colleagues,

Scientific research on food supplements and nutraceutical products is tracking the rapid growth of the related market. Many pharma companies are orienting part of their interest toward this area of health products, focusing on the great potentiality of natural compounds and on the recent discoveries of biological and biochemical studies on herbs and other natural sources.

To prompt such an alignment between market requests and scientifically sound research, in the most recent years, some delivery and targeting strategies, thus far applied to drugs and pharmaceutical compounds, have been proposed to also release, in a controlled or selective manner, natural bioactive molecules which are useful in the development of food-grade products.

This Special Issue aims to collect the most recent experiences and ideas in the application of controlled release approaches, including micro- and nanoencapsulation in lipid or polymeric biomaterials, to this wide area of health research.

Prof. Dr. Rosario Pignatello
Guest Editor

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Keywords

  • nutraceuticals

  • food supplements
  • fortified food
  • controlled release
  • modified release
  • targeting
  • gut
  • colon delivery
  • biopolymers
  • microencapsulation
  • nanoparticles
  • drug delivery

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Published Papers (1 paper)

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Research

12 pages, 2409 KiB  
Article
Nanostructured Lipid Carriers Loaded with Cannabidiol Enhance Its Bioaccessibility to the Small Intestine
by Lucia Grifoni, Giulia Vanti and Anna Rita Bilia
Nutraceuticals 2023, 3(2), 210-221; https://doi.org/10.3390/nutraceuticals3020016 - 13 Apr 2023
Cited by 3 | Viewed by 2753
Abstract
The purpose of this study was to investigate the loading properties of the non-psychoactive cannabidiol (CBD) in a new nanostructured lipid carrier (NLC), evaluating its bioaccessibility in gastric and intestinal simulated physiological media. CBD has a low water solubility, as well as high [...] Read more.
The purpose of this study was to investigate the loading properties of the non-psychoactive cannabidiol (CBD) in a new nanostructured lipid carrier (NLC), evaluating its bioaccessibility in gastric and intestinal simulated physiological media. CBD has a low water solubility, as well as high instability in simulated physiological conditions and in the acidic media, which results in a very low bioavailability—less than 6%. NLCs containing CBD (10 mg/mL), Compritol 888 ATO, Lauroglycol 90, Labrafil 2125, Tween 20, and Poloxamer 188 were formulated. This resulted in them being suitable for oral administration because the size was less than 200 nm, polydispersity index 0.152, and ζ-potential −39.21 ± 1.89 mV. Recovery and encapsulation efficiency were 100% and 93%, respectively. After two hours of incubation in simulated gastric fluid (SGF), NLCs remained unchanged, protecting CBD from acidic medium. Indeed, CBD is also reported to be not stable in media with pH = 7.4 at 37 °C, but our studies evidenced that in the presence of the intestinal fluid, the NLC was digested and formed an emulsion, which can protect and preserve the CBD chemical structure, as confirmed by the 100% recovery found after six hours. Accordingly, CBD-loaded NLCs are a promising oral formulation that optimize bioaccessibility in the small intestine. Full article
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