Special Issue "Non-Coding RNA in Multiple Myeloma"

A special issue of Non-Coding RNA (ISSN 2311-553X).

Deadline for manuscript submissions: 31 August 2019

Special Issue Editors

Guest Editor
Prof. Antonino Neri

Department of Oncology and Hemato-oncology, University of Milan and Hematology, Fondazione IRCCS Ospedale Maggiore Policlinico
Website | E-Mail
Interests: lymphoid malignancies; multiple myeloma; molecular pathogenesis; transcriptome; non coding RNA
Guest Editor
Dr. Luca Agnelli

Department of Oncology and Hemato-oncology, University of Milan
Website | E-Mail
Interests: lymphoid malignancies; bioinformatics and biostatistics in cancer; -omics analyses; next generation sequencing; non coding RNA

Special Issue Information

Dear Colleagues,

Multiple Myeloma is one of the most common and aggressive hematologic tumors, characterized by different subtypes, presentation and clinical course. The definition of molecular and prognostic subgroups is affected by great genomic and transcriptional heterogeneity mostly, but not exclusively, associated with structural rearrangements (ploidy alteration, translocations, gene mutations). In the last years, several studies using high-throughput technologies have contributed to depict in details the genetic architecture of the disease. Despite the great amount of data and with few exception, however, molecular features have not been used so far to drive treatment and the Myeloma community is still far from consensus in defining driver events that might be target of personalized therapy.

In this context, a further level of complexity is represented by the role of the non-coding fraction of RNA, whose investigation is adding important elements to the comprehension of the transcriptional milieu in multiple myeloma. To date, major evidences of correlation with coding transcriptome and genomic lesions have emerged involving the small non-coding RNA (ncRNA) fraction, primarily miRNA and snoRNA. In particular, several studies have investigated the expression profiles of small ncRNA and associated them to molecular and genomic features and to prognosis, providing effective disease stratification that might also overpower those reported in classical gene expression-based studies. In that, miRNAs undoubtedly offer a solid substrate for the study of future potential therapeutic interventions. Moreover, the importance of ncRNA is not limited to malignant plasma cells but should be considered in the context of the tumor bone marrow microenvironment (stromal and mesenchymal stem cells), in cell-cell communication mechanisms and in serum as circulating molecules. The most recent researches, additionally, have highlighted that also long non-coding RNAs (lncRNAs) expression levels are modulated in myeloma and their deregulation is candidate for a role in the disease.

The present Special Issue is aimed at collecting latest advances and outstanding researches investigating non-coding RNA involved in myeloma. Specifically, we will consider Original Research and Review manuscripts of great interest for scientists involved in the field.
The main arguments that manuscripts will deal with include, but are not limited to, the following topics:

  • Discovery and investigation of novel non-coding RNAs involved in plasma cell biology
  • ncRNAs deregulation in multiple myeloma and plasma cells dyscrasias
  • ncRNA to improve stratification and outcome prediction in myeloma
  • Functional roles of ncRNAs in malignant plasma cells, tumor microenvironment, and serum
  • ncRNA transcriptional network and epigenetic mechanisms in myeloma cells
  • Pre-clinical studies investigating the role of ncRNA in myeloma

Prof. Antonino Neri
Dr. Luca Agnelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Multiple myeloma
  • Plasma cell dyscrasia
  • ncRNA
  • Long ncRNA (lncRNA)
  • miRNA
  • snoRNA
  • Bone marrow microenvironment
  • Exosomes
  • Circulating serum miRNA

Published Papers (3 papers)

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Review

Open AccessReview
Circulating microRNAs and Their Role in Multiple Myeloma
Non-Coding RNA 2019, 5(2), 37; https://doi.org/10.3390/ncrna5020037
Received: 13 March 2019 / Revised: 26 April 2019 / Accepted: 30 April 2019 / Published: 2 May 2019
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Abstract
Multiple myeloma (MM) is a plasma cell dyscrasia characterized by bone marrow infiltration of clonal plasma cells. The recent literature has clearly demonstrated clonal heterogeneity in terms of both the genomic and transcriptomic signature of the tumor. Of note, novel studies have also [...] Read more.
Multiple myeloma (MM) is a plasma cell dyscrasia characterized by bone marrow infiltration of clonal plasma cells. The recent literature has clearly demonstrated clonal heterogeneity in terms of both the genomic and transcriptomic signature of the tumor. Of note, novel studies have also highlighted the importance of the functional cross-talk between the tumor clone and the surrounding bone marrow milieu, as a relevant player of MM pathogenesis. These findings have certainly enhanced our understanding of the underlying mechanisms supporting MM pathogenesis and disease progression. Within the specific field of small non-coding RNA-research, recent studies have provided evidence for considering microRNAs as a crucial regulator of MM biology and, in this context, circulating microRNAs have been shown to potentially contribute to prognostic stratification of MM patients. The present review will summarize the most recent studies within the specific topic of microRNAs and circulating microRNAs in MM. Full article
(This article belongs to the Special Issue Non-Coding RNA in Multiple Myeloma)
Open AccessReview
Long Non-Coding RNAs in Multiple Myeloma
Non-Coding RNA 2019, 5(1), 13; https://doi.org/10.3390/ncrna5010013
Received: 16 November 2018 / Revised: 15 January 2019 / Accepted: 15 January 2019 / Published: 24 January 2019
Cited by 1 | PDF Full-text (638 KB) | HTML Full-text | XML Full-text
Abstract
Multiple myeloma (MM) is the second most common hematooncological disease of malignant plasma cells in the bone marrow. While new treatment brought unprecedented increase of survival of patients, MM pathogenesis is yet to be clarified. Increasing evidence of expression of long non-coding RNA [...] Read more.
Multiple myeloma (MM) is the second most common hematooncological disease of malignant plasma cells in the bone marrow. While new treatment brought unprecedented increase of survival of patients, MM pathogenesis is yet to be clarified. Increasing evidence of expression of long non-coding RNA molecules (lncRNA) linked to development and progression of many tumors suggested their important role in tumorigenesis. To date, over 15,000 lncRNA molecules characterized by diversity of function and specificity of cell distribution were identified in the human genome. Due to their involvement in proliferation, apoptosis, metabolism, and differentiation, they have a key role in the biological processes and pathogenesis of many diseases, including MM. This review summarizes current knowledge of non-coding RNAs (ncRNA), especially lncRNAs, and their role in MM pathogenesis. Undeniable involvement of lncRNAs in MM development suggests their potential as biomarkers. Full article
(This article belongs to the Special Issue Non-Coding RNA in Multiple Myeloma)
Figures

Graphical abstract

Open AccessReview
Factors Regulating microRNA Expression and Function in Multiple Myeloma
Non-Coding RNA 2019, 5(1), 9; https://doi.org/10.3390/ncrna5010009
Received: 30 October 2018 / Revised: 13 January 2019 / Accepted: 15 January 2019 / Published: 16 January 2019
Cited by 1 | PDF Full-text (2174 KB) | HTML Full-text | XML Full-text
Abstract
Intensive research has been undertaken during the last decade to identify the implication of microRNAs (miRNAs) in the pathogenesis of multiple myeloma (MM). The expression profiling of miRNAs in MM has provided relevant information, demonstrating different patterns of miRNA expression depending on the [...] Read more.
Intensive research has been undertaken during the last decade to identify the implication of microRNAs (miRNAs) in the pathogenesis of multiple myeloma (MM). The expression profiling of miRNAs in MM has provided relevant information, demonstrating different patterns of miRNA expression depending on the genetic abnormalities of MM and a key role of some miRNAs regulating critical genes associated with MM pathogenesis. However, the underlying causes of abnormal expression of miRNAs in myeloma cells remain mainly elusive. The final expression of the mature miRNAs is subject to multiple regulation mechanisms, such as copy number alterations, CpG methylation or transcription factors, together with impairment in miRNA biogenesis and differences in availability of the mRNA target sequence. In this review, we summarize the available knowledge about the factors involved in the regulation of miRNA expression and functionality in MM. Full article
(This article belongs to the Special Issue Non-Coding RNA in Multiple Myeloma)
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Figure 1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1) Alberto Rocci et al. ncRNA to improve stratification and clinical outcome in Myeloma.

2) Norma Gutierrez et al. ncRNA transcriptional network and epigenetic mechanisms in myeloma cells.

3) Cinzia Federico and Aldo Roccaro. Circulating microRNAs and their role in multiple myeloma.

4) Caraglia Michele and Misso Gabriella. Mir-34a as a target and molecular biomarker in multiple myeloma and other haematological malignancies.

5) Sabina Ševčíková and Roman Hájek.  Long non-coding RNA molecules in multiple myeloma.

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