Magnetic Nanomaterials as Theranostic Platform in Cancer Treatment and Diagnosis
A special issue of Nanomaterials (ISSN 2079-4991).
Deadline for manuscript submissions: closed (20 October 2021) | Viewed by 10513
Special Issue Editors
Interests: nanomedicine; cancer therapy; autophagy; ROS; nanoparticles; chemotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This multidisciplinary Special Issue of Nanomaterials focuses on the application of magnetic nanomaterials in cancer treatment and diagnosis and encourages basic and translational scientists working in a related field to submit original research articles and review articles. Today, radiotherapy and chemotherapy are the principal medical therapeutic approaches against cancer. However, the efficacy of these treatments is often limited by a number of unwanted side-effects associated with nonselective and unspecific cytotoxicity. In recent years, nanotechnology has attracted significant interests in cancer therapeutics because of its huge potential to offer many innovative tools to overcome the problems arising from present chemotherapy and radiotherapy approaches. The intersection between the fields of chemistry, physics, and material sciences has created theranostics nanomaterials which are defined as the combination of therapeutic and diagnostic agents within a single platform and are expected to improve the efficacy of treatment of many tumors resistant to traditional therapeutic approaches, as well as to provide novel diagnostic tools. In particular, magnetic nanoparticles, because of their unique physical, chemical, mechanical, and optical properties, have intrinsic cytotoxicity and/or enhance the efficacy of standard chemotherapies. Moreover, magnetic nanoparticles are used as nanocarriers, since they can be easily modified in order to deliver therapeutic molecules, such as drugs, proteins, or nucleic acids. Important advantages of these therapeutic nanostructures concern, as well, their external controllability by different stimuli in order to produce a cytotoxic effect through the delivery of local heating by the application of an external magnetic field or optical near infrared radiation depending on their composition and physical properties. These functions can be utilized for therapeutic hyperthermia of cancer but also for controlled release of cancer drugs through the application of an external magnetic field. Finally, magnetic nanomaterials can also be exploited to favor the delivery of immune agents and can represent a valid therapeutic tool to bypass the obstacles currently encountered in cancer immunotherapy. These innovative biomedical applications are currently exploited in a variety of clinical trials and in the near future may represent a major improvement in the therapy of cancer. In this regard, magnetic nanoparticles can be used as platform materials for theranostics application by offering advantages and opportunities as drug delivery systems and nanodiagnostics, decreasing the side-effects of standard therapies. We aim to receive submissions addressed on recent advances in the broad and fascinating field of functional magnetic nanomaterials for therapeutic and diagnostic purposes.
Dr. Marco Cordani
Dr. Ana Espinosa
Guest Editors
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Keywords
- cancer treatment
- magnetic nanomaterials for drug delivery in cancer
- therapeutic nucleic acids
- magnetic and photothermal therapy in cancer
- magnetic nanomaterials for diagnostic applications
- modulation of immune response by magnetic nanoparticles
- modulation of autophagy
- regulation of oxidative stress
- modulation of EMT and fibrosis
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