Special Issue "Organic Nanomaterials in Biomedicine: Applications and Perspectives"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: closed (17 July 2019).

Special Issue Editor

Dr. Giovanni Signore
E-Mail Website
Guest Editor
Scuola Normale Superiore
Interests: 1: development of organic-based, targeted nanostructures for drug delivery. Particular interest is paid to the issue of protein (more specifically enzyme) delivery in specific subcellular compartments (lysosomes and cytoplasm); 2: development of fluorescent probes for intracellular sensing of physico-chemical properties, tailored to better diagnosis and understanding of molecular mechanisms underlying pathological states
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Special Issue Information

Dear Colleagues,

In recent years, organic-based nanomaterials have emerged as a powerful tool in diagnostics and therapeutics and hold the potential of becoming a disruptive technology compared with the currently used clinical approaches, because they may allow to attain a high loading efficiency with drugs and biomolecules. The tuneable surface chemistry—based on simple chemical modifications—allows to modulate the interactions with tissues and cells, leading to selective and efficient binding of biomolecules and improved biodistribution. In this Special Issue, we would like to invite you to submit an original research paper or review paper, which deals with the synthesis and application in biomedicine of organic-based nanomaterials. Topics of interest include the design and characterization of innovative nanostructures, the evaluation of their interactions with biological environments (including intracellular trafficking and interaction with serum proteins), and their use as diagnostic tools. Particular attention will be devoted to the role of targeting sequences in determining the fate of nanomaterials in vitro and in vivo. Novel applications in emerging fields, such as lysosomal and cytoplasmic protein and miRNA delivery, are welcome.

Dr. Giovanni Signore
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • targeting
  • controlled release
  • protein delivery
  • protein corona

Published Papers (1 paper)

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Nanocarriers for Protein Delivery to the Cytosol: Assessing the Endosomal Escape of Poly(Lactide-co-Glycolide)-Poly(Ethylene Imine) Nanoparticles
Nanomaterials 2019, 9(4), 652; https://doi.org/10.3390/nano9040652 - 23 Apr 2019
Cited by 11 | Viewed by 1814
Therapeutic proteins and enzymes are a group of interesting candidates for the treatment of numerous diseases, but they often require a carrier to avoid degradation and rapid clearance in vivo. To this end, organic nanoparticles (NPs) represent an excellent choice due to their [...] Read more.
Therapeutic proteins and enzymes are a group of interesting candidates for the treatment of numerous diseases, but they often require a carrier to avoid degradation and rapid clearance in vivo. To this end, organic nanoparticles (NPs) represent an excellent choice due to their biocompatibility, and cross-linked enzyme aggregates (CLEAs)-loaded poly (lactide-co-glycolide) (PLGA) NPs have recently attracted attention as versatile tools for targeted enzyme delivery. However, PLGA NPs are taken up by cells via endocytosis and are typically trafficked into lysosomes, while many therapeutic proteins and enzymes should reach the cellular cytosol to perform their activity. Here, we designed a CLEAs-based system implemented with a cationic endosomal escape agent (poly(ethylene imine), PEI) to extend the use of CLEA NPs also to cytosolic enzymes. We demonstrated that our system can deliver protein payloads at cytoplasm level by two different mechanisms: Endosomal escape and direct translocation. Finally, we applied this system to the cytoplasmic delivery of a therapeutically relevant enzyme (superoxide dismutase, SOD) in vitro. Full article
(This article belongs to the Special Issue Organic Nanomaterials in Biomedicine: Applications and Perspectives)
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