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Nanomaterials
Special Issues
Nanobiocomposite Materials: Synthesis, Properties and Applications
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Nanobiocomposite Materials: Synthesis, Properties and Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 15 April 2026 | Viewed by 2505

Special Issue Editor

Prof. Dr. Mieczyslaw Jurczyk

E-Mail Website
Guest Editor
Department of Biomedical Engineering, Institute of Material and Biomedical Engineering, Faculty of Engineering and Technology, University of Zielona Góra, Prof. Z. Szafrana 4 Street, 65-516 Zielona Gora, Poland
Interests: nanoscience; nanotechnology; nanostructured materials; powder metallurgy; microstructure; X-ray diffraction; phase transition; porous metallic nanobiomaterials; nanobiocomposites; biocompatibility

Special Issue Information

Dear Colleagues,

Nanobiocomposites as a new class of materials formed by a combination of natural and inorganic materials (metals, ceramics, polymers, and graphene) at the nanoscale dimension are foreseen to change tissue engineering and bone implant applications due to their improved corrosion resistance, mechanical properties, biocompatibility, and antimicrobial activity. The branches where nanotechnology has become popular, apart from implantology, are tooth regeneration, periodontal therapy, soft and hard tissue reconstruction, bone repair, plaque control, caries diagnostics, and caries treatments. Improvement of tissue integration of nanocomposite implants can be achieved by modification of the surface roughness at the nanoscale level for increasing protein adsorption and cell adhesion, by biomimetic calcium phosphate coatings for enhancing osteoconduction, and by the addition of biological drugs for accelerating the bone healing process in the peri-implant area.

The scope of this Special Issue is to illustrate the most recent research on the production, characterization, properties, and broad applications of nanobiocomposites, as well as to cover the current challenges and opportunities in their medical acceptance. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: nanotechnology, metallic, ceramic and polymeric nanobiocomposites, preparation, surface modification, structure, corrosion, electrochemical and mechanical properties, biocompatibility and bioactivity, biomedical applications, and medical implants.

Prof. Dr. Mieczyslaw Jurczyk
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanotechnology
  • metallic and ceramic nanobiocomposites
  • polymeric nanobiocomposites
  • preparation
  • surface modification
  • properties
  • antimicrobial activity
  • biomedical applications
  • medical implants

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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12 pages, 1363 KB  
Article
Physical Properties of New Silica-Based Denture Surface Coating
by Kazuhiro Akutsu-Suyama, Reiko Tokuyama-Toda, Chiaki Tsutsumi-Arai, Chika Terada-Ito, Yoko Iwamiya, Zenji Hiroi, Mitsuhiro Shibayama and Kazuhito Satomura
Nanomaterials 2025, 15(21), 1652; https://doi.org/10.3390/nano15211652 - 29 Oct 2025
Viewed by 522
Abstract
Denture stomatitis is a common issue among denture users, primarily caused by pathogenic microorganisms such as Candida albicans that adhere to and multiply on the denture surface. While previous approaches have focused on incorporating antimicrobial agents into denture base resins, this study introduces [...] Read more.
Denture stomatitis is a common issue among denture users, primarily caused by pathogenic microorganisms such as Candida albicans that adhere to and multiply on the denture surface. While previous approaches have focused on incorporating antimicrobial agents into denture base resins, this study introduces a novel surface coating strategy for polymethyl-methacrylate (PMMA) using hinokitiol—a natural antibacterial and antifungal compound derived from Hiba. This method enables the formation of a uniform silica–resin layer containing hinokitiol, achieved through a simple immersion process. Using X-ray and neutron reflectivity techniques, we discovered that a uniform silica–resin layer could form on PMMA with significant amounts of hinokitiol present. Time-dependent neutron reflectivity analysis revealed the presence of the following two types of hinokitiol molecules within the silica–resin layer: one type desorbs rapidly with weak capture near the surface, and the other desorbs slowly with strong capture near the PMMA interface, facilitated by hydrogen bonding in the silica–resin nanopores. These findings demonstrate a new mechanism for controlled release of antimicrobial agents from denture surfaces and highlight the potential of this coating technique as a practical and effective strategy for preventing denture-related infections. Full article
(This article belongs to the Special Issue Nanobiocomposite Materials: Synthesis, Properties and Applications)
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14 pages, 1566 KB  
Article
Development of Silica Nanoparticles Embedded Adipose Spheroid Platform for Probing Bacteriophage Sequestration and Its Implications for Phage Therapy
by Rafael Levandowski, Su Yati Htun and Laura Ha
Nanomaterials 2025, 15(19), 1537; https://doi.org/10.3390/nano15191537 - 9 Oct 2025
Viewed by 546
Abstract
We engineer an enhanced three-dimensional (3D) adipose model by integrating mesoporous silica (mSiO2) nanoparticles into human adipose-derived stem cell spheroids. The mSiO2 is highly cytocompatible, enables stable dispersion, and yields spheroids that preserve structural integrity and roundness for at least [...] Read more.
We engineer an enhanced three-dimensional (3D) adipose model by integrating mesoporous silica (mSiO2) nanoparticles into human adipose-derived stem cell spheroids. The mSiO2 is highly cytocompatible, enables stable dispersion, and yields spheroids that preserve structural integrity and roundness for at least 14 days, accompanied by higher metabolic activity and reduced hypoxic stress. Under adipogenic induction, the nanoparticles embedded spheroids exhibit deeper lipid accumulation and increased expression of PPARγ, adiponectin, and FABP4. As a proof of concept, we leveraged this 3D platform to examine phage uptake and tissue-level distribution in adipose spheroids in comparison with conventional 2D cultures. These experiments reveal that both the cellular differentiation state and the tissue architecture govern phage association and uptake. Together, our findings indicate that phages engage mammalian cells beyond their bacterial hosts, a consideration that should inform future phage therapy design with implications for innate immune responses and overall therapeutic efficacy. Full article
(This article belongs to the Special Issue Nanobiocomposite Materials: Synthesis, Properties and Applications)
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Review

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38 pages, 6969 KB  
Review
Nanotechnology for Biomedical Applications: Synthesis and Properties of Ti-Based Nanocomposites
by Maciej Tulinski, Mieczyslawa U. Jurczyk, Katarzyna Arkusz, Marek Nowak and Mieczyslaw Jurczyk
Nanomaterials 2025, 15(18), 1417; https://doi.org/10.3390/nano15181417 - 15 Sep 2025
Viewed by 1126
Abstract
Nanobiocomposites are a class of biomaterials that include at least one phase with constituents in the nanometer range. Nanobiocomposites, a new class of materials formed by combining natural and inorganic materials (metals, ceramics, polymers, and graphene) at the nanoscale dimension, are expected to [...] Read more.
Nanobiocomposites are a class of biomaterials that include at least one phase with constituents in the nanometer range. Nanobiocomposites, a new class of materials formed by combining natural and inorganic materials (metals, ceramics, polymers, and graphene) at the nanoscale dimension, are expected to revolutionize tissue engineering and bone implant applications because of their enhanced corrosion resistance, mechanical properties, biocompatibility, and antimicrobial activity. Titanium-based nanocomposites are gaining attention in biomedical applications due to their exceptional biocompatibility, corrosion resistance, and mechanical properties. These composites typically consist of a titanium or titanium alloy matrix that is embedded with nanoscale bioactive phases, such as hydroxyapatite, bioactive glass, polymers, or carbon-based nanomaterials. Common methods for synthesizing Ti-based nanobiocomposites and their parts, including bottom-up and top-down approaches, are presented and discussed. The synthesis conditions and appropriate functionalization influence the final properties of nanobiomaterials. By modifying the surface roughness at the nanoscale level, composite implants can be enhanced to improve tissue integration, leading to increased cell adhesion and protein adsorption. The objective of this review is to illustrate the most recent research on the synthesis and properties of Ti-based biocomposites and their scaffolds. Full article
(This article belongs to the Special Issue Nanobiocomposite Materials: Synthesis, Properties and Applications)
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