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Microorganisms
Special Issues
Research on Microbial Periprosthetic Infections
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Research on Microbial Periprosthetic Infections

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Biofilm".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 5448

Special Issue Editors

Dr. Hesham Abdelbary

E-Mail Website
Guest Editor
Department of Surgery, Division of Orthopaedics, The Ottawa Hospital, Ottawa, ON, Canada
Interests: phage; periprosthetic infections
Special Issues, Collections and Topics in MDPI journals
Dr. George Grammatopoulos

E-Mail Website
Guest Editor
Ottawa Hospital, Ottawa, ON, Canada
Interests: orthopedic surgery; hip and knee replacement
Dr. Simon Garceau

E-Mail Website
Guest Editor
Department of Surgery, University of Ottawa, Ottawa, ON, Canada
Interests: periprosthetic joint infection; antibiotic

Special Issue Information

Dear Colleagues,

Implantable medical devices have revolutionized the care provided for patients suffering from a diverse spectrum of medical conditions. Unfortunately, a common complication that hampers the intended benefit of any implanted medical device is periprosthetic infection, with biofilm formation on infected implant surfaces being one of the main the main culprits that poses a significant therapeutic challenge for current standard antimicrobial therapies.

The Special Issue aims to present recent research related to periprosthetic infections, with a focus on, among other potential themes, biofilm biology on various implant surfaces, local and systemic host responses to biofilm formation, approaches to treat and prevent biofilm formation, economic and functional implications of periprosthetic infections. Reviews, original research and communications will be welcome.

Dr. Hesham Abdelbary
Dr. George Grammatopoulos
Dr. Simon Garceau
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biofilm
  • implant surface
  • immune system
  • delivery mechanisms
  • antibiotic resistance

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

12 pages, 12021 KiB  
Article
Mapping Staphylococcus aureus at Early and Late Stages of Infection in a Clinically Representative Hip Prosthetic Joint Infection Rat Model
by Mariam Taha, Abdullah AlDuwaisan, Manijeh Daneshmand, Mazen M. Ibrahim, Jonathan Bourget-Murray, George Grammatopoulos, Simon Garceau and Hesham Abdelbary
Microorganisms 2024, 12(9), 1895; https://doi.org/10.3390/microorganisms12091895 - 14 Sep 2024
Viewed by 1369
Abstract
Prosthetic joint infection (PJI) continues to be a devastating complication following total joint replacement surgeries where Staphylococcus aureus is the main offending organism. To improve our understanding of the disease pathogenesis, a histological analysis of infected peri-implant tissue in a hip PJI rat [...] Read more.
Prosthetic joint infection (PJI) continues to be a devastating complication following total joint replacement surgeries where Staphylococcus aureus is the main offending organism. To improve our understanding of the disease pathogenesis, a histological analysis of infected peri-implant tissue in a hip PJI rat model was utilized to assess S. aureus spread and tissue reaction at early and late stages of infection. Sprague–Dawley rats were used and received a left cemented hip hemiarthroplasty using a 3D-printed titanium femoral stem. The rats received an intra-articular injection of S. aureus Xen36. These infected rats were sacrificed either at 3 days post-infection (early-stage infection) or at 13-days post-infection (late-stage infection). The femoral and acetabular tissues of all animals were harvested at euthanasia. Histological analysis for the harvested tissue was performed using immunohistochemistry, hematoxylin and eosin, as well as Masson’s trichrome stains. Histological examination revealed significant quantitative and qualitative differences in peri-implant tissue response to infection at early and late stages. This hip PJI rat model identified clear histologic differences between early and late stages of S. aureus infection and how quickly bacterial infiltration could occur. These findings can provide insight into why certain surgical strategies like debridement and antibiotics may be associated with high failure rates. Full article
(This article belongs to the Special Issue Research on Microbial Periprosthetic Infections)
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10 pages, 426 KiB  
Article
Longitudinal Outcomes Following Mitral Valve Repair for Infective Endocarditis
by Yuan Qiu, Lawrence Lau, Zaim Khan, David Messika-Zeitoun, Marc Ruel and Vincent Chan
Microorganisms 2024, 12(9), 1809; https://doi.org/10.3390/microorganisms12091809 - 1 Sep 2024
Cited by 1 | Viewed by 1103
Abstract
Mitral valve repair is the ideal approach in managing mitral valve infective endocarditis for patients requiring surgery. However, viable repair is influenced by the extent of valve destruction and there can be technical challenges in reconstruction following debridement. Overall, data describing long-term outcomes [...] Read more.
Mitral valve repair is the ideal approach in managing mitral valve infective endocarditis for patients requiring surgery. However, viable repair is influenced by the extent of valve destruction and there can be technical challenges in reconstruction following debridement. Overall, data describing long-term outcomes following mitral repair of infective endocarditis are scarce. We, therefore, assessed the late outcomes of 101 consecutive patients who underwent mitral valve repair for IE at the University of Ottawa Heart Institute from 2001 to 2021. The 5- and 10-year survival rate was 80.8 ± 4.7% and 61.2 ± 9.2%, respectively. Among these 101 patients, 7 ultimately required mitral valve reoperation at a median of 5 years after their initial operation. These patients were of a mean age of 35.9 ± 7.3 years (range 22–44 years) at the time of their initial operation. The 5- and 10-year freedom from mitral valve reoperation was 93.6 ± 3.4% and 87.7 ± 5.2%, respectively. Overall, mitral valve repair can be an effective method for treating infective endocarditis with a favourable freedom from reoperation and mortality over the long term. Full article
(This article belongs to the Special Issue Research on Microbial Periprosthetic Infections)
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11 pages, 486 KiB  
Article
The Impact of Culture Negativity on the Outcomes of Revision Total Knee Arthroplasty for Chronic PJI
by Emily M. Ronan, Garrett Ruff, Itay Ashkenazi, Hayley Raymond, Casey Cardillo, Jordan C. Villa, Ran Schwarzkopf and Vinay K. Aggarwal
Microorganisms 2024, 12(7), 1384; https://doi.org/10.3390/microorganisms12071384 - 8 Jul 2024
Viewed by 1384
Abstract
Culture-positive (CP) and culture-negative (CN) periprosthetic joint infections (PJI) remain a crucial area of research; however, current studies comparing these infections rely on unstandardized outcome reporting tools. Our study aimed to compare the outcomes of two-stage revision of CP and CN PJI using [...] Read more.
Culture-positive (CP) and culture-negative (CN) periprosthetic joint infections (PJI) remain a crucial area of research; however, current studies comparing these infections rely on unstandardized outcome reporting tools. Our study aimed to compare the outcomes of two-stage revision of CP and CN PJI using the standardized Musculoskeletal Infection Society (MSIS) outcome reporting tool. We retrospectively reviewed 138 patients who were diagnosed with PJI and indicated for two-stage revision total knee arthroplasty (rTKA). The majority of patients in both CP and CN cohorts achieved infection control without the need for reoperation (54.1% and 62.5%, respectively). There was a significant difference in the overall distribution of MSIS outcomes (p = 0.043), with a significantly greater rate of CN patients falling into Tier 1 (infection control without the use of suppressive antibiotics) (52.5% versus 29.6%, p = 0.011). There was also a significant difference in the distribution of septic versus aseptic reoperations after 2nd stage (p = 0.013), with more CP reoperations being septic and more CN reoperations being aseptic. The duration from first to second stage was significantly shorter in the CN cohort (p = 0.002). While overall infection control was similar between cohorts, these data suggest that the outcomes of two-stage rTKA are favorable in cases of CN PJI. Full article
(This article belongs to the Special Issue Research on Microbial Periprosthetic Infections)
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