Development of Antimicrobial and Anti-biofilm Agents

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 346

Special Issue Editors

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Guest Editor
Department of STEBICEF, Università degli Studi di Palermo, Palermo, Italy
Interests: antimicrobial peptides; antibiofilm agents; antivirulence agents; antimicrobial nanoparticles; biomedical systems with antimicrobial and antibiofilm properties
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Earth and Marine Sciences (DiSTeM), University of Palermo, Palermo, Italy
Interests: molecular microbiology; antimicrobials; antibiofilm activity; antimicrobial peptides; antivirulence drugs; antibiotic resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antibiotics represent one of the pillars upon which modern medicine is based. Therefore, the phenomenon of antibiotic resistance (AMR), which limits or cancels the effectiveness of these molecules, is a serious global health problem. Antibiotic resistance may develop at the level of the single bacterial cell (adaptative resistance) or the community level (natural resistance), which involves the switch from a free-living life form (planktonic) to a sessile multistratified community (biofilm). Biofilms consist of a matrix where a multitude of bacterial cells are encased. The biofilm’s matrix limits the penetration of some classes of antibiotics; in addition, the deepest layers of biofilms contain bacterial subpopulations that are endowed with low metabolic activity and growth rate and are therefore intrinsically resistant to conventional antibiotics. Moreover, the biofilm is an ideal ecological niche for the horizontal transfer of antibiotic resistance genes among bacteria. The formation of biofilms is associated with multidrug resistance and complicates the treatment of infections in patients with vascular, valvular and orthopedic prosthesis.

The focus of this Special Issue is on agents (organic molecules, peptides, phages, etc.) which target the molecular determinants of virulence- and biofilm-associated multifactorial resistance. Another very promising field aims at improving the activity of known antibiotics in the development of nano- and microdelivery systems or delivery via functionalized polymers.

Dr. Domenico Schillaci
Dr. Valentina Catania
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • antivirulence agents
  • antimicrobial peptides
  • quorum sensing inhibitors
  • phage therapy
  • antimicrobial nanoparticles

Published Papers

There is no accepted submissions to this special issue at this moment.
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