Metabolic and Biophysical Simulations in the Systems Medicine of Obese-Related Diseases
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Bioinformatics and Data Analysis".
Deadline for manuscript submissions: closed (15 February 2022) | Viewed by 329
Special Issue Editors
Interests: metabolic modeling; high-throughput multi-omics data; biophysical simulations; liver disease
Interests: systems biochemistry; liver; computational modeling
Special Issue Information
Dear Colleagues,
Obesity refers to a metabolic state of the human body where the lipid mass stored in the adipose tissue results in a body mass index (BMI) greater than 30 kg/m2. If this state persists for a period of months to years, it severely increases the risk of developing type 2 diabetes and cardiovascular diseases. Currently, numerous molecular processes at cellular and tissue levels driving the progression from healthy overweight to the most severe case of unhealthy obesity—metabolic syndrome—have been identified. Model-based computer simulations may help to integrate all these details into a consistent systemic understanding. Therefore, the aim of this Special Issue is to collect original research publications on metabolic and biophysical simulation models addressing various aspects of obesity-related diseases, such as:
- Expansion of the (white) adipose tissue and development of insulin resistance and a low-inflammatory state;
- Lipid accumulation (steatosis) in ectopic organs (liver, kidney, muscle) and related changes in cell metabolism and tissue architecture;
- Loss of metabolic flexibility in skeletal muscle and heart;
- Disorder in metabolic and signaling pathways of pancreatic β-cells;
- Dysregulation of lipoprotein metabolism and development of atheroma;
- Aberrant mechanics during weight-induced additional locomotor tasks and stress within connective-tissue structures.
Reports looking at or even bridging different scales from cell, tissue, organ to systemic metabolic modeling will be highly appreciated.
Dr. Nikolaus Berndt
Prof. Dr. Hermann-Georg Holzhütter
Guest Editors
Manuscript Submission Information
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