Isotopomics Applications in Plant, Animal, and Human Metabolisms

Dear Colleagues,

Since the term “isotopomics” was introduced by G. Tcherkez in 2007 to describe multiple isotopic signatures within biological systems, the use of stable isotopes at natural abundance in plant, animal, and human metabolism has been more important than ever. The cornerstone of all these applications is the involvement of isotope effects, resulting from a discrimination during biochemical processes and leading to specific isotopic signatures of metabolites, or atom positions within metabolites. This Special Issue shows how the utilization of isotopomics has been successful to better understand metabolic pathways and define useful metabolic biomarkers. It includes (i) observation of isotope fractionations in a broad range of biological, biomedical, environmental, agricultural, and nutritional research fields, (ii) novel techniques for isotopomics, such as nuclear magnetic resonance (NMR), high-resolution mass spectroscopy (MS), isotope ratio MS (IRMS), and inductively coupled plasma MS (ICP-MS), and (iii) integration of isotopomics to other omics approaches (metabolomics) to disentangle metabolic pathways and bottlenecks involved in diseases or physiological responses to the environment.

Dr. Illa Tea
Guest Editor

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• Stable isotopes
• Isotopomics
• Biomarkers
• Metabolism