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Metabolites
Special Issues
Metabolic Properties of Microbial Cells or Enzymes
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Metabolic Properties of Microbial Cells or Enzymes

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Microbiology and Ecological Metabolomics".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 1784

Special Issue Editors

Dr. Wei Zeng

E-Mail Website
Guest Editor
1. Key Laboratory of Biochemistry and Molecular Biology (Guilin Medical University), Education Department of Guangxi Zhuang Autonomous Region, 1 Zhiyuan Road, Guilin 541199, China
2. School of Intelligent Medicine and Biotechnology, Guilin Medical University, 1 Zhiyuan Road, Guilin 541199, China
Interests: metabolic engineering; enzyme engineering; fermentation engineering; biochemical engineering; synthetic biology
Dr. Hao Wu

E-Mail Website
Guest Editor
School of Food Science and Bioengineering, Changsha University of Science and Technology, Changsha 410114, China
Interests: synthetic biology; metabolic engineering; protein engineering

Special Issue Information

Dear Colleagues,

Metabolism is the sum of various catabolism and anabolism processes occurring in living cells, and its essence is the catalysis of enzymes. There is a whole set of extremely precise metabolic control systems in microbial cells, which ensures that thousands of enzymes in the cells carry out complex metabolic reactions in an orderly manner, thereby producing various metabolites. In recent years, researchers have used various advanced artificial technologies, such as metabolic engineering, enzyme engineering, synthetic biology, etc., to obtain mutant strains or even new strains that break through metabolic regulation. These strains can industrially produce various valuable metabolites, such as antibiotics, vitamins, amino acids, lipids, saccharides, nucleotides, enzymes, etc.

This Special issue on “Metabolic Properties of Microbial Cells or Enzymes” will publish reviews and original articles covering the latest use of metabolic engineering, enzyme engineering, synthetic biology, and other technologies to modify the metabolic properties of microbial cells or enzymes and efficiently synthesize various metabolites that can be applied in medicine, food, agriculture, industry, and other fields.

Furthermore, new technologies and methods for studying the metabolic properties of microbial cells or enzymes will be addressed.

Dr. Wei Zeng
Dr. Hao Wu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbial cell
  • enzyme
  • metabolic property
  • metabolites
  • metabolic engineering
  • enzyme engineering
  • synthetic biology

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Published Papers (1 paper)

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Research

13 pages, 866 KiB  
Article
In Vivo Effectiveness of Pleurotus ostreatus in Degradation of Toxic Metabolites of Filamentous Fungi Such as Aflatoxin B1 and Zearalenone
by Agnieszka Zapaśnik, Marcin Bryła, Adrian Wojtczak and Barbara Sokołowska
Metabolites 2025, 15(1), 20; https://doi.org/10.3390/metabo15010020 - 5 Jan 2025
Cited by 1 | Viewed by 1171
Abstract
Background/Objectives: Mycotoxins, secondary metabolites synthesized by filamentous fungi, have been classified as dangerous substances and proven to be carcinogenic, as well as to have genotoxic, nephrotoxic, hepatotoxic, teratogenic, and mutagenic properties. Despite numerous trials to develop an effective and safe-for-human-health method of detoxification, [...] Read more.
Background/Objectives: Mycotoxins, secondary metabolites synthesized by filamentous fungi, have been classified as dangerous substances and proven to be carcinogenic, as well as to have genotoxic, nephrotoxic, hepatotoxic, teratogenic, and mutagenic properties. Despite numerous trials to develop an effective and safe-for-human-health method of detoxification, there is still a high risk associated with the occurrence of these toxins in food and feed. Biological methods of food preservation are an alternative option to conventional chemical and physical methods, characterized by their less negative impact on human health as well as their high efficiency against filamentous fungi and other foodborne pathogens. Mycoremediation is a new biotechnique based on the capability of fungi to detoxify matrices from various pullulans. Ligninolytic enzymes produced by white rot fungi (WRF) characterize a high efficiency in the degradation of various mycotoxins. Methods: In our study, Pleurotus ostreatus, as a representative of WRF, was cultivated on a medium contaminated by AFB1 and ZEN (mushroom substrate and maize) in a few variants of concentration. After the cultivation, medium and fruiting bodies were collected and analyzed with the usage of HPLC and LC/MS methods. Results: The reduction oscillated between 53 and 87% (AFB1) and 73 and 97% (ZEN) depending on the initial concentration of toxins in the medium. Grown fruiting bodies contained insignificant amounts of both toxins. Conclusions: These findings confirm the potential of P. ostreatus as an effective biological agent for reducing mycotoxins in contaminated medium, highlighting its applicability in developing sustainable and safe methods for detoxification. Full article
(This article belongs to the Special Issue Metabolic Properties of Microbial Cells or Enzymes)
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