Composition and Biophysical Properties of Lipid Membranes

A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Biological Membranes".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1422

Special Issue Editor


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Guest Editor
LAQV/REQUIMTE (Laboratório Associado para a Química Verde—Rede de Química e Tecnologia), Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, s/n, 4169-007 Porto, Portugal
Interests: biophysics; microbiology; antimicrobial agents; porins; bacteria

Special Issue Information

Dear Colleagues,

Membranes are key components of cells, comprising mainly lipids, proteins, and carbohydrates, which are involved in signaling and cell recognition. The membrane composition modulates its properties, as fluidity, phase behavior, asymmetry, permeability, and elasticity, and undergoes changes in (patho)physiological conditions, which impact membrane-driven processes. Therefore, insights on membrane’s biophysical features are crucial to improve the knowledge on molecular membrane mechanisms. Therefore, mimetic membrane model systems have been widely used for the biophysical characterization of membranes through isothermal titration calorimetry, surface plasmon resonance, Langmuir isotherms, dynamic light scattering, circular dichroism spectroscopy, atomic force microscopy, UV–vis and fluorescence spectroscopy, confocal microscopy, small-angle X-ray scattering, and computational biophysical methods, among others.

This Special Issue aims to provide a platform for different biophysical approaches regarding the composition and biophysical properties of lipid membranes. I am pleased to invite you to submit manuscripts, including original research articles or reviews.

I am looking forward to receiving your contributions to the Special Issue ‘Composition and Biophysical Properties of Lipid Membranes’.

Dr. Mariana Ferreira
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mimetic membrane model systems
  • membrane permeability
  • membrane dynamics
  • cell recognition and signaling
  • lipid rafts
  • lipid–protein interactions
  • biophysical methods

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Published Papers (1 paper)

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Research

16 pages, 5006 KiB  
Article
Insights on Hydrogen Bond Network of Water in Phospholipid Membranes: An Infrared Study at Varying Hydration
by Valeria Conti Nibali, Caterina Branca, Ulderico Wanderlingh, Rosaria Verduci, Elisa Bonaccorso, Andrea Ciccolo and Giovanna D’Angelo
Membranes 2025, 15(2), 46; https://doi.org/10.3390/membranes15020046 - 4 Feb 2025
Viewed by 934
Abstract
Water in membrane interphases is vital for cellular biological functions, but despite its importance, the structure and function of biological water remain elusive. Here, by studying the OH stretching mode in partially hydrated lipid multilayers by FTIR measurements, relevant information on the water [...] Read more.
Water in membrane interphases is vital for cellular biological functions, but despite its importance, the structure and function of biological water remain elusive. Here, by studying the OH stretching mode in partially hydrated lipid multilayers by FTIR measurements, relevant information on the water structure near the surface with lipid membranes has been gathered. The water hydrogen bond network is highly perturbed in the first layers that are in contact with the lipid membrane, exhibiting strong deviations from tetrahedral symmetry and a significant number of defects, such as isolated water molecules and a large number of hydrogen-bonded water dimers in the interphase region. These findings support the hypothesis that water chains form in phospholipid membranes, and are involved in the proton transfer across lipid bilayers by phosphate groups of opposing lipids. Furthermore, we have determined that even at very low hydration levels, a small amount of water is embedded within the confined spaces of the hydrocarbon region of phospholipid bilayers, which could potentially contribute to the structural stability of the lipid membrane. Full article
(This article belongs to the Special Issue Composition and Biophysical Properties of Lipid Membranes)
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