The Role of Lipoproteins and Cell Membrane Lipids in Disease
A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Biological Membrane Functions".
Deadline for manuscript submissions: closed (20 May 2022) | Viewed by 9411
Special Issue Editor
Interests: coronary artery disease; coronary artery spasm; myocardial ischemia; heart failure; electrocardiography
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Lipoproteins are complex particles that have a central hydrophobic core of non-polar lipids, primarily cholesterol esters and triglycerides, which is surrounded by a hydrophilic membrane consisting of phospholipids, free cholesterol, and apolipoproteins. Disorders of lipoproteins often lead to disease in humans. The sequelae of long-term dyslipoproteinemia often lead to atherosclerotic vascular disease in all arterial beds. The plasma elevation of low-density lipoprotein cholesterol, very low-density lipoproteins and lipoprotein(a), and reduced levels of high-density lipoprotein cholesterol are risk factors for coronary artery disease. Severe elevations of plasma triglycerides may lead to acute pancreatitis.
Oxidative stress resulting from cell metabolism, as well as from extracellular processes, is recognized as one of the primary processes underlying the initiation and progression of miscellaneous disorders. Because of the close interactions of plasma lipoproteins with vascular endothelial cells and the susceptibility of their surface lipids to oxidative modification, plasma lipoproteins are good biological sensors of oxidative stress in the vessel wall. Therefore, understanding the susceptibility of lipoproteins and cell membrane lipids to oxidative modification is essential for preventing the development of affected diseases.
The aim of this Special Issue is to provide update data linking changes in the oxidative modifications of lipoproteins, membrane lipid peroxidation and disease development.
This Special Issue aims to promote studies focused on lipoproteins and cell membrane lipids (e.g., small dense low-density lipoprotein, lipoprotein(a)) and disease, including reviews and experimental studies.
Kind regards,
Dr. Ming-Yow Hung
Guest Editor
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Keywords
- oxidative stress
- lipoproteins
- lipids
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