Hematopoietic Stem Cell Transplantation: Current Trends and Future Perspectives
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Hematology and Immunology".
Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 176
Special Issue Editors
Interests: haploidentical HSCT; infectious complications; graft manipulation; immune reconstitution; GVHD
Special Issues, Collections and Topics in MDPI journals
Interests: allogeneic stem cell transplantation; immune reconstitution; infectious and immunological complications after Hsct
Special Issue Information
Dear Colleagues,
Hematopoietic stem cell transplantation (HSCT) was first explored for use in humans in the 1950s. Since then, the use of allogeneic and autologous stem cell transplants has increased worldwide. Due to emerging therapies (drugs, carT, …), in recent years the HSCT has lost indication in some diseases (like B-ALL or lymphoproliferative disorders).
Conversely, its role is importantly changing in terms of indication and eligibility in other diseases, like T-ALL, autoimmune disease, and/or hemoglobinopathies (above all sickle cell disease) due to a better understanding of biology of these disease, but also biology of transplant. The knowledge and progresses made in the field of therapy-as-a-bridge-to-transplant, HLA compatibility, conditioning regimens, manipulation of the graft (above all in the haplo setting), graft-versus-host disease (GVHD) prophylaxis and treatment, and in management of complications, like VOD, infections, and/or organ toxicity, have significantly improved the outcome of transplants, even in disease types in which transplant-related mortality was high.
This Special Issue will focus on the role of autologous and allogenic HSCT in the new era of Car-T cell, gene therapy, “personalized” therapy, and precision medicine, with new evidence and indications.
For this Special Issue, original research articles, narrative reviews, scoping reviews, and systematic reviews with meta-analysis are invited to help improve clinical management.
Dr. Lucia Prezioso
Dr. Federica Galaverna
Guest Editors
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Keywords
- allogenic stem cell transplantation
- GVHD, infections
- stem cell manipulation
- acute myeloid leukemia
- acute lymphoblastic leukemia
- lymphoproliferative disorders
- hemoglobinopathies
- autoimmune disease
- immune reconstitution
- minimal residual disease
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