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Marine Drugs
Special Issues
Marine Natural Products as Anti-Cancer Agents
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Marine Natural Products as Anti-Cancer Agents

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 May 2008) | Viewed by 12299

Special Issue Editor

Prof. Dr. Jordan K. Zjawiony

E-Mail Website
Guest Editor
Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, MS 38677, USA
Interests: marine biotechnology; pharmacognosy; natural products; semisynthesis; medicinal chemistry

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Published Papers (1 paper)

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Research

101 KiB  
Article
Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A
by Gerhard Bringmann, Tobias A. M. Gulder, Gerhard Lang, Stefanie Schmitt, Rüdiger Stöhr, Jutta Wiese, Kerstin Nagel and Johannes F. Imhoff
Mar. Drugs 2007, 5(2), 23-30; https://doi.org/10.3390/md502023 - 25 Jun 2007
Cited by 52 | Viewed by 11927
Abstract
In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have [...] Read more.
In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies. Full article
(This article belongs to the Special Issue Marine Natural Products as Anti-Cancer Agents)
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