Project Collection "TASCMAR"

A project collection of Marine Drugs (ISSN 1660-3397).

Papers displayed on this page all arise from the same project. Editorial decisions were made independently of project staff and handled by the Editor-in-Chief or qualified Editorial Board members.

Editors

Dr. Anne Bialecki

Collection Editor
Faculté des Sciences et Technologies, Université de la Réunion, 15 Avenue René Cassin, BP 7151, 97 715 Saint Denis Messag. Cedex, Ile de la Réunion, France
Dr. Jamal Ouazzani

Collection Editor
Institut de Chimie des Substances Naturelles ICSN, CNRS, avenue de la Terrasse, 91198 Gif sur Yvette, cedex, France
Dr. Ioannis Trougakos

Collection Editor
Department of Cell Biology & Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Zografou, Athens 15784, Greece

Project Overview

Dear Colleagues,

TASCMAR (Tools And Strategies to access original bioactive compounds by Cultivating MARine invertebrates and associated symbionts) is a European Commission funded project aspiring to develop new tools and strategies to overcome existing bottlenecks in the discovery and industrial exploitation of marine-derived biomolecules (secondary metabolites and enzymes) with applications in the pharmaceutical, nutraceutical and cosmeceutical industries. Exploitation of neglected and underutilized marine invertebrates and symbionts from the mesophotic zone will be combined with innovative approaches for the cultivation and extraction of marine organisms, from lab to pilot-scale, including the construction of new biotechnological equipment. This approach will ensure the sustainable supply of biomass while promoting the production of high added value bioactive marine compounds. State-of-the-art analytical instrumentation and in-house databases will be employed for the dereplication and characterisation of valuable compounds and a focused panel of in vitro, cell-based, in ovo and in vivo bioassays, for discovering metabolites with anti-ageing and/or angiogenesis modulating activity, will guide the project’s workflow to reveal the lead compounds. In addition, the catalytic potential of mesophotic symbionts and deriving enzyme candidates will be evaluated in the fine chemicals and bioremediation industries. TASCMAR will be continuously evaluated for its socioeconomic and environmental impact in order to balance industrial development and sustainable growth. The project also aims to develop higher standards for bioprospecting in areas of rich marine biodiversity.

Dr. Anne Bialecki
Dr. Jamal Ouazzani
Dr. Ioannis Trougakos
Project Leaders 

Keywords

  • mesophotic coral ecosystems (MCEs)
  • age-related diseases
  • marine invertebrate holobionts
  • marine micobial symbionts
  • marine secondary metabolites
  • marine-derived biocatalysts

Published Papers (2 papers)

2019

Jump to: 2018

Open AccessArticle
New Antimalarial and Antimicrobial Tryptamine Derivatives from the Marine Sponge Fascaplysinopsis reticulata
Mar. Drugs 2019, 17(3), 167; https://doi.org/10.3390/md17030167 - 15 Mar 2019
Cited by 1
Abstract
Chemical study of the CH2Cl2-MeOH (1:1) extract of the sponge Fascaplysinopsis reticulata collected in Mayotte highlighted three new tryptophan derived alkaloids, 6,6′-bis-(debromo)-gelliusine F (1), 6-bromo-8,1′-dihydro-isoplysin A (2) and 5,6-dibromo-8,1′-dihydro-isoplysin A (3), along with [...] Read more.
Chemical study of the CH2Cl2-MeOH (1:1) extract of the sponge Fascaplysinopsis reticulata collected in Mayotte highlighted three new tryptophan derived alkaloids, 6,6′-bis-(debromo)-gelliusine F (1), 6-bromo-8,1′-dihydro-isoplysin A (2) and 5,6-dibromo-8,1′-dihydro-isoplysin A (3), along with the synthetically known 8-oxo-tryptamine (4) and the three known molecules from the same family, tryptamine (5), (E)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (6) and (Z)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (7). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their antimicrobial and their antiplasmodial activities. Regarding antimicrobial activities, the best compounds are (2) and (3), with minimum inhibitory concentration (MIC) of 0.01 and 1 µg/mL, respectively, towards Vibrio natrigens, and (5), with MIC values of 1 µg/mL towards Vibrio carchariae. In addition the known 8-oxo-tryptamine (4) and the mixture of the (E)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (6) and (Z)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (7) showed moderate antiplasmodial activity against Plasmodium falciparum with IC50 values of 8.8 and 8.0 µg/mL, respectively. Full article
Show Figures

Graphical abstract

2018

Jump to: 2019

Open AccessArticle
Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis
Mar. Drugs 2018, 16(5), 146; https://doi.org/10.3390/md16050146 - 27 Apr 2018
Cited by 3
Abstract
Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 29 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric [...] Read more.
Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 29 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 μM and 1.3 μM, respectively. Full article
Show Figures

Graphical abstract

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