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Mar. Drugs 2018, 16(5), 146; https://doi.org/10.3390/md16050146

Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis

1
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, University Paris-Sud, University of Paris-Saclay, 1, Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France
2
Organic Chemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
3
LEMAR, IRD, UBO, CNRS, IFREMER, IUEM, 29280 Plouzané, France
4
CRIOBE, CNRS, EPHE, UPVD, PSL Research University, 98729 Moorea, French Polynesia
5
Observatoire Océanologique de Banyuls-sur-Mer, Université Pierre et Marie Curie Paris, 66650 Banyuls-sur-Mer, France
6
EIO, UPF, ILM, IFREMER, IRD, Faa’a, 98702 Tahiti, French Polynesia
*
Authors to whom correspondence should be addressed.
Received: 29 March 2018 / Revised: 19 April 2018 / Accepted: 24 April 2018 / Published: 27 April 2018
(This article belongs to the Collection TASCMAR)
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Abstract

Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 29 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 μM and 1.3 μM, respectively. View Full-Text
Keywords: brominated tyrosine alkaloids; Suberea ianthelliformis; cytotoxicity; acetylcholinesterase inhibition brominated tyrosine alkaloids; Suberea ianthelliformis; cytotoxicity; acetylcholinesterase inhibition
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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El-Demerdash, A.; Moriou, C.; Toullec, J.; Besson, M.; Soulet, S.; Schmitt, N.; Petek, S.; Lecchini, D.; Debitus, C.; Al-Mourabit, A. Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis. Mar. Drugs 2018, 16, 146.

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