Eutectic Solvents as Alternatives for Extracting Biologically Active Compounds from Marine Natural Products

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 681

Special Issue Editors


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Guest Editor
Faculté de Pharmacie, Université de Tours, 31 Avenue Monge, 37200 Tours, France
Interests: deep eutectic solvents; microalgae; process optimization; centrifugal partition chromatography; biorefinery

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Guest Editor
LAQV, Requimte, Departamento de Química, Nova School of Science and Technology, 2829-516 Caparica, Portugal
Interests: green chemistry; deep eutectic systems; drug discovery; pharmaceuticals; extraction
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Special Issue Information

Dear Colleagues,

Marine biomasses are a significant source of new molecules for pharmaceutical, nutraceutical, and cosmetic applications. However, their extraction, formulation, or stabilization can cause environmental issues. To address this, deep eutectic solvents (DES) and low transition temperature mixtures (LTTM) offer a promising alternative for the valorization of marine molecules of interest. These new multifunctional solvents can offer significant benefits for pre-treating biomass, extracting or purifying molecules of interest, and stabilizing or formulating them.

For this Special Issue, we invite academic and industrial scientists to submit original research articles and conceptual reviews that highlight the use of DES or LTTM for the valorization of metabolites of marine origin.

Prof. Dr. Leslie Boudesocque-Delaye
Dr. Ana Rita Xavier De Jesus Gameiro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • eutectic solvents
  • marine biomasses
  • nutraceutics
  • cosmetics
  • health
  • biorefinery
  • extraction processes
  • formulations processes
  • metabolite stabilization
  • by-product valorization

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Published Papers (1 paper)

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Review

17 pages, 1271 KiB  
Review
Deep Eutectic Systems: A Game Changer for Marine Bioactives Recovery
by Sandro Amador, Alice Martins, Margarida Matias, Rui Pedrosa and Susete Pinteus
Mar. Drugs 2025, 23(5), 211; https://doi.org/10.3390/md23050211 - 16 May 2025
Viewed by 196
Abstract
The extraction of bioactive compounds from marine natural products has gained increasing attention due to their diverse applications, such as in pharmaceuticals, nutraceuticals, and cosmetics. Yet, low extraction yields and toxicity associated with common solvents are a major bottleneck. Deep eutectic solvents (DESs) [...] Read more.
The extraction of bioactive compounds from marine natural products has gained increasing attention due to their diverse applications, such as in pharmaceuticals, nutraceuticals, and cosmetics. Yet, low extraction yields and toxicity associated with common solvents are a major bottleneck. Deep eutectic solvents (DESs) and natural deep eutectic solvents (NADESs) have emerged as promising green alternatives to conventional organic solvents, offering advantages such as biodegradability, greater environmental and economic sustainability, low toxicity, and enhanced extraction selectivity. This review provides a comprehensive analysis of the principles, physicochemical properties, and applications of DESs/NADESs to obtain bioactive compounds from marine organisms. Among the most recent works, it is possible to verify the success of NADESs to extract carrageenan from the seaweed Kappaphycus alvarezii; pigments from Palmaria palmata; and polyphenols and proteins from different brown seaweeds. NADESs have also shown high potential to extract other valuable compounds from marine by-products, such as chitin from crabs and shrimp shells, and also lipids and proteins from different fish species and protein rich extracts from tilapia viscera. The challenges for DESs/NADESs use at industrial scale are also discussed, and success cases are revealed, highlighting their potential as game changers for extracting bioactive compounds from marine organisms and driving the development of innovative biotechnological products. Full article
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