Special Issue "Marine-Inspired Regenerative Strategies for Chronic Diseases"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (20 January 2022) | Viewed by 2759

Special Issue Editors

Prof. Dr. Mary Murphy
E-Mail Website
Guest Editor
National University of Ireland Galway, Galway, Ireland
Interests: stem cell biology; regenerative medicine; osteoarthritis; chronic degenerative diseases
Dr. Pietro Marchese
E-Mail
Guest Editor
National University of Ireland Galway, Galway, Ireland
Interests: stem cell biology; regenerative medicine; osteoarthritis; chronic degenerative diseases

Special Issue Information

Dear Colleagues,

Chronic diseases of the musculoskeletal system are one of the primary causes of disability worldwide and often lack effective pharmacological treatments. The regenerative approach to restoring organ function aims to re-establish physiological conditions to act on local or implanted progenitor cells. Tissue regeneration is achieved through the administration of stem/progenitor cells, their differentiated progeny or, in some cases, secretomes. Local or systemic treatment is possible with stimulation through small molecules or growth factors and the use of biomaterials such as biopolymers or ceramics. However, current strategies do not sufficiently address clinical needs and there is an urgent need for the discovery of new bioactive compounds or biomaterials to efficiently stimulate stem cell activities. The ocean is the most extensive and the least studied environment on Earth, hosting huge biodiversity, chemodiversity and potential for drug discovery. Research of bioactive marine compounds for regenerative medicine has great potential to contribute to the development of novel treatments for painful conditions affecting millions of people worldwide.

Prof. Dr. Mary Murphy
Dr. Pietro Marchese
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Marine natural products
  • Regenerative medicine
  • Tissue engineering
  • Stem cells
  • Stem cell differentiation
  • High throughput screening
  • Chronic diseases

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Article
Deep-Sea Coral Garden Invertebrates and Their Associated Fungi Are Genetic Resources for Chronic Disease Drug Discovery
Mar. Drugs 2021, 19(7), 390; https://doi.org/10.3390/md19070390 - 13 Jul 2021
Cited by 5 | Viewed by 2392
Abstract
Chronic diseases characterized by bone and cartilage loss are associated with a reduced ability of progenitor cells to regenerate new tissues in an inflammatory environment. A promising strategy to treat such diseases is based on tissue repair mediated by human mesenchymal stem cells [...] Read more.
Chronic diseases characterized by bone and cartilage loss are associated with a reduced ability of progenitor cells to regenerate new tissues in an inflammatory environment. A promising strategy to treat such diseases is based on tissue repair mediated by human mesenchymal stem cells (hMSCs), but therapeutic outcomes are hindered by the absence of small molecules to efficiently modulate cell behaviour. Here, we applied a high-throughput drug screening technology to bioprospect a large library of extracts from Irish deep-sea organisms to induce hMSC differentiation toward musculoskeletal lineages and reduce inflammation of activated macrophages. The library included extracts from deep-sea corals, sponges and filamentous fungi representing a novel source of compounds for the targeted bioactivity. A validated hit rate of 3.4% was recorded from the invertebrate library, with cold water sea pens (octocoral order Pennatulacea), such as Kophobelemnon sp. and Anthoptilum sp., showing the most promising results in influencing stem cell differentiation toward osteogenic and chondrogenic lineages. Extracts obtained from deep-sea fungi showed no effects on stem cell differentiation, but a 6.8% hit rate in reducing the inflammation of activated macrophages. Our results demonstrate the potential of deep-sea organisms to synthetize pro-differentiation and immunomodulatory compounds that may represent potential drug development candidates to treat chronic musculoskeletal diseases. Full article
(This article belongs to the Special Issue Marine-Inspired Regenerative Strategies for Chronic Diseases)
Show Figures

Figure 1

Back to TopTop