Genomics-Guided Drug Discovery from Ocean Microbiome
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 7248
Special Issue Editors
Interests: larval omics; marine molecular ecology; microbial ecology; marine natural products; biofouling and antifouling; marine invertebrates
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This ocean environment with extremely high biomass and biodiversity not only provides food for us, but also offers a vast untapped genetic pool with medicinal and biotechnical potential. Particularly, the ocean microbiome produces diverse natural products such as signal molecules and antibiotics that mediate communication and competition, and are a vast unexplored source for drug discovery. Recently advances in metabolomics and genomics, combined with emerging synthetic biology strategies, are rapidly changing the landscape of microbial natural product discovery. Recent metagenome mining of the ocean microbiome revealed the huge biosynthetic potential of natural products hidden in the uncultivated microbiomes, the vast majority of which are still “orphans”.
The ocean microbiome presents an untapped source for natural product discovery. Novel integrated approaches that combine genomics, metabolomics, and synthetic biology strategies are recently applied to harness the chemical potential of the microbiome for targeted natural product discovery. This Special Issue invites articles from both genomics- and synthetic biology-enabled studies on ocean microbiomes with a focus on natural product discovery and characterization. We particularly welcome articles that combine genomics, metabolomics, and synthetic biology approach for the discovery of marine bacterial natural products.
Prof. Dr. Peiyuan Qian
Dr. Yongxin Li
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- ocean microbiome
- drug discovery
- natural products
- secondary metabolites
- omics
- genome mining
- metabolic analysis
- synthetic biology
- biosynthesis
