Latest Progress in Hepatobiliary Surgery Research

A special issue of Livers (ISSN 2673-4389).

Deadline for manuscript submissions: closed (16 April 2026) | Viewed by 1838

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Guest Editor
2nd Department of Propaedeutic Surgery, National and Kapodistrian University of Athens, Athens, Greece
Interests: hepatobiliary; surgery; hepatocellular carcinoma; hcc; cholangiocarcinoma; intrahepatic colorectal cancer; liver metastasis; hepatectomy; transplantation
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Special Issue Information

Dear Colleagues,

This Special Issue, “Latest Progress in Hepatobiliary Surgery Research”, seeks to present recent advances and contemporary perspectives in the field of hepatobiliary surgery. The scope includes, but is not limited to, developments in surgical techniques, perioperative care, minimally invasive and robotic approaches, liver transplantation, oncological outcomes, and translational research relevant to hepatobiliary disease. We particularly encourage the submission of original research articles, high-quality reviews, and clinical studies that contribute to improved understanding and management of hepatobiliary conditions. By gathering contributions from researchers worldwide, this Special Issue aims to provide a comprehensive overview of the current progress and future directions, thereby serving as a valuable resource for both clinical practice and academic research.

Dr. Nikolaos Machairas
Guest Editor

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Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Livers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hepatobiliary surgery
  • liver transplantation
  • minimally invasive surgery
  • robotic surgery
  • perioperative management
  • hepatic oncology
  • cholangiocarcinoma
  • hepatocellular carcinoma
  • surgical innovation
  • translational research

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Published Papers (1 paper)

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13 pages, 3109 KB  
Systematic Review
Surgical Decision-Making and Clinical Characteristics in Porcelain Gallbladder: A Systematic Review of Case Reports
by Osvaldo Huchim-Mendez, Ruben R. Lozano-Salazar, Alejandro D. Munive-Ramirez, Jorge E. Mendicuti-Carrillo, Erick Rochel-Perez and Nina Isabel Mendez Dominguez
Livers 2026, 6(3), 47; https://doi.org/10.3390/livers6030047 - 2 Jun 2026
Viewed by 972
Abstract
Porcelain gallbladder (PGB) has historically been considered a premalignant condition, although recent evidence questions the strength of its association with gallbladder carcinoma. Objective: To describe the occurrence and characteristics of malignancy in patients with porcelain gallbladder, as well as clinical, imaging, and [...] Read more.
Porcelain gallbladder (PGB) has historically been considered a premalignant condition, although recent evidence questions the strength of its association with gallbladder carcinoma. Objective: To describe the occurrence and characteristics of malignancy in patients with porcelain gallbladder, as well as clinical, imaging, and surgical characteristics reported in clinal cases. Methods: A systematic review of case reports and case series (≤5 patients) was conducted following PRISMA 2020 guidelines. PubMed/MEDLINE, ScienceDirect, and Redalyc from database inception through March 2026. Individual patient data were extracted including demographic characteristics, imaging findings, calcification pattern, surgical management, histopathology, and outcomes. Descriptive statistics were performed. Results: Fifty-four individual cases of porcelain gallbladder were identified. Patients were predominantly female (70.4%), with ages ranging from 6 to 98 years. Complete calcification was reported in 85.2% of cases. Histopathological confirmation was available in 45 cases (83.3%). Thirteen patients had gallbladder carcinoma associated with porcelain gallbladder, corresponding to 28.9% of those with pathological examinations. Incomplete calcification showed higher frequency of malignancy compared with complete calcification. Mortality was reported in three patients (5.6%), all with malignant disease. Conclusions: The proportion of malignancy observed in published case reports reflects a selected dataset and should not be interpreted as an estimate of population risk. These findings provide descriptive insights into clinical presentations and management patterns, supporting hypothesis generation rather than risk estimation. Full article
(This article belongs to the Special Issue Latest Progress in Hepatobiliary Surgery Research)
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