Microplastics in the Environment: Intake Through the Food Chain and Cosmeceuticals, Human Exposure, and Health Concerns

A special issue of Journal of Xenobiotics (ISSN 2039-4713).

Deadline for manuscript submissions: 30 September 2026 | Viewed by 7924

Special Issue Editors


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Guest Editor
Institute of Multidisciplinary Research for Science and Technology, Valahia University of Targoviste, 13 Sinaia Alley, 130004 Targoviste, Romania
Interests: heavy metals spectrometry

E-Mail Website
Guest Editor
1. Department of Science and Advanced Technologies, Faculty of Science and Arts, VALAHIA University of Targoviste, 13 Sinaia Alley, 130004 Targoviste, Romania
2. Doctoral School Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, Polizu no 1, 011061 Bucharest, Romania
3. Academy of Romanian Scientists, 3 Ilfov 050044, 050044 Bucharest, Romania
Interests: microplastics; cosmetic formulations; vibrational spectroscopy; health risk; chromatography; microencapsulation
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Special Issue Information

Dear Colleagues,

In the past decade, microplastics (MPs) have become a worldwide concern due to their harmful effects on the environment and human health. Understanding the origin, formation, and transport of these particles is crucial to identifying their impacts on ecosystems and human well-being. Microplastics are found in water, soil, air, food chains, and various cosmetic formulations, representing a worldwide threat. In addition, microplastic particles are found in the bodies of animals, but also of humans, in ever-increasing amounts. It is essential to understand how microplastics are formed, how they spread, and how they affect ecosystems and humans in terms of exposure and intake. This knowledge is key to developing effective strategies for preventing, remediating, and managing their presence.

Currently, manufacturers create a wide range of products that significantly enhance the daily joys and pleasures of modern life. New products undergo regular safety testing and are often test-marketed to confirm that consumers recognize their advertised benefits. In particular, while there is little support for the regulation of cosmetics to be the same as drugs, there is a clear need for some form of compromise regarding cosmeceutical regulation. If cosmetic products are safe and beneficial, consumers will be satisfied and use them to enhance their mood and well-being. On the other hand, in urban environments, MPs mainly originate from the wear of car tires, shoes, factories, or air transport. These particles are carried by wind and, in isolated areas, settle on the ground or in water, where they can ultimately be inhaled by people. In the human body, these particles are deposited in the lungs, potentially contributing to issues such as a weakened immune system and various diseases such as infertility, nervous system problems, hearing loss, and even cancer.

Submissions may examine topics including, but not limited to, the following: (i) the particle size of MPs, in conjunction with analytical investigations regarding their chemical composition, as well as the risks of compositionally modified food/drugs/cosmeceuticals on human health; (ii) the way food, breeding, processing, transport, geographical conditions, etc., are analyzed statistically in order to establish well-founded hypotheses and interpretations regarding the source–cause–effect relationship of MPs; (iii) the origin/source of MPs contamination; and (iv) assessments of MPs’ impact on human health (e.g., adults and children) and potential health outcomes. We also invite contributions on topics other than the above areas, but which still fit within the scope of this Special Issue.

Dr. Raluca Maria Ştirbescu
Prof. Dr. Cristiana Radulescu
Guest Editors

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Keywords

  • microplastics
  • environment
  • food chain
  • cosmeceuticals
  • micro-FTIR
  • micro-Raman
  • thermoanalytical techniques
  • health risk
  • human concern

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Published Papers (3 papers)

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Research

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29 pages, 4828 KB  
Article
Identification, Quantification, and Characterization of Microplastics in Skincare and Treatment Creams: A Potential Health Concern Related to the Exposure Pathway
by Raluca Maria Stirbescu, Cristiana Radulescu, Raluca Maria Bucur (Popa), Andreea Laura Banica, Ioan Alin Bucurica and Ioana Daniela Dulama
J. Xenobiot. 2026, 16(1), 37; https://doi.org/10.3390/jox16010037 - 22 Feb 2026
Cited by 1 | Viewed by 867
Abstract
This research aimed to quantify and investigate the morphology of microplastics in skincare and treatment creams related to their chemical composition and the potential risks to human health associated with exposure to microplastics by dermal contact. A total of 21 skincare and treatment [...] Read more.
This research aimed to quantify and investigate the morphology of microplastics in skincare and treatment creams related to their chemical composition and the potential risks to human health associated with exposure to microplastics by dermal contact. A total of 21 skincare and treatment cream samples, indicating the target audience (men, women, and children) for each product, and potential diseases were analyzed in terms of the hidden risk of microplastics. To determine the exact number of microplastics to which adults and children are exposed over the course of a year, in-depth research was conducted on the cosmetic care and treatment products used by over 354 respondents from Romania. This study used a free, self-reported questionnaire method, which took into account consumer habits and preferences, as well as any potential medical conditions that could affect exposure. Optical microscopy and micro-FTIR revealed a total of 109 microplastics, with different sizes, colors, and shapes (i.e., fragments and fibers) and various chemical compositions, including mixtures of polymeric and natural structures, as well as 100% synthetic materials, e.g., polyethylene and polyester. The potential health risk of exposure to microplastics in certain cosmetic formulations for adults was assessed by calculating various risk indices, such as the polymer risk index (H), pollution load index (PLI), dermal plastic absorption (DPA), chronic daily dermal exposure (CDDE), risk to human health from dermal absorption (RHHDA), and estimated annual dermal absorption (EADA). These indices were calculated based on the medical conditions and application areas indicated on the labels of the analyzed creams (i.e., skincare and treatment), for both adult and children’s categories, using the fingertip unit (FTU) method for estimating the cream amount. The plastic toxicity of the analyzed samples was assessed using the H and PLI indices. The risk of microplastics to human health from dermal exposure was assessed using the DPA, CDDE, RHHDA, and EADA indices, which showed concerning results regarding the presence of these particles in cosmetic formulations. Full article
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31 pages, 2112 KB  
Review
Micro- and Nanoplastics Exposure Across the Lifespan: One Health Implications for Aging and Longevity
by Chantalle Moulton, Anna Baroni and Ennio Tasciotti
J. Xenobiot. 2026, 16(2), 52; https://doi.org/10.3390/jox16020052 - 19 Mar 2026
Viewed by 954
Abstract
Micro- and nanoplastics (MNPs) are pervasive environmental contaminants with growing relevance for human health across the lifespan. Older adults may be especially vulnerable to their effects due to cumulative lifetime exposure, age-related physiological changes, and a higher burden of chronic disease. Adopting a [...] Read more.
Micro- and nanoplastics (MNPs) are pervasive environmental contaminants with growing relevance for human health across the lifespan. Older adults may be especially vulnerable to their effects due to cumulative lifetime exposure, age-related physiological changes, and a higher burden of chronic disease. Adopting a One Health perspective, this review synthesizes current evidence on the sources, exposure pathways, and biological effects of MNPs, integrating findings from environmental, animal, and human studies with a specific focus on aging populations. Experimental studies consistently show that MNP exposure triggers oxidative stress, inflammation, mitochondrial dysfunction, and cellular senescence, mechanisms central to biological aging. These processes are linked to dysfunction of the cardiovascular, nervous, gastrointestinal, and immune systems, suggesting that MNPs may contribute to the development or progression of age-related diseases. Within the One Health framework, MNPs also act as carriers of chemical additives and environmental pollutants, potentially amplifying health risks through combined and cumulative exposures along food chains and ecosystems. Despite increasing mechanistic evidence, direct epidemiological data in older adults remain limited. This review highlights key knowledge gaps and emphasizes the need for integrative, longitudinal research to clarify the role of MNPs in aging and to inform public health and environmental policy. Full article
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30 pages, 3062 KB  
Review
Separation and Detection of Microplastics in Human Exposure Pathways: Challenges, Analytical Techniques, and Emerging Solutions
by Asim Laeeq Khan and Asad A. Zaidi
J. Xenobiot. 2025, 15(5), 154; https://doi.org/10.3390/jox15050154 - 23 Sep 2025
Cited by 9 | Viewed by 5418
Abstract
Microplastics (MPs) are increasingly recognized as widespread environmental contaminants, with confirmed presence in human tissues and biological fluids through ingestion, inhalation, and direct systemic exposure. Their potential impacts on human health have become an important subject of scientific investigation. The detection and quantification [...] Read more.
Microplastics (MPs) are increasingly recognized as widespread environmental contaminants, with confirmed presence in human tissues and biological fluids through ingestion, inhalation, and direct systemic exposure. Their potential impacts on human health have become an important subject of scientific investigation. The detection and quantification of MPs, particularly nanoplastics, in complex biological matrices remain challenging because of their low concentrations, diverse physicochemical properties, and interference from organic and inorganic matter. This review presents a critical assessment of current methods for the separation and detection of MPs from human-relevant samples. It examines pre-treatment, separation, and analytical approaches including physical filtration, density-based separation, chemical and enzymatic digestion, vibrational spectroscopy, thermal analysis, and electron microscopy, highlighting their principles, advantages, and limitations. Key challenges such as low sample throughput, absence of standardized procedures, and the difficulty of nanoplastic detection are identified as major barriers to accurate exposure assessment and risk evaluation. Recent advances, including functionalized adsorbents, improved anti-fouling membranes, integrated microfluidic systems, and artificial intelligence-assisted spectral analysis, are discussed for their potential to provide sensitive, scalable, and standardized analytical workflows. By integrating current challenges with recent innovations, this review aims to guide multidisciplinary research toward the development of reliable and reproducible detection strategies that can support MPs exposure assessment and inform evidence-based health policies. Full article
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