New Perspectives on Filamentous and Dimorphic Fungi Research

A special issue of Journal of Fungi (ISSN 2309-608X).

Deadline for manuscript submissions: closed (20 February 2024) | Viewed by 1951

Special Issue Editors


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Proteomics Center, Mycology Laboratory, UNESP, School of Pharmaceutical Sciences, State University, Araraquara, SP, Brazil
Interests: endemic mycoses; biofilm; virulence factors; adhesins; antifungal
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School of Microbiology, Universidad de Antioquia (UdeA), Medellín, Colombia
Interests: fungal-host interactions; diagnostic; immunology; mycology; animal models; stem cells
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Laboratory of Medical Investigation Units 53 and 56, Division of Clinical Dermatology, Clinics Hospital, and Laboratory of Medical Mycology, Institute of Tropical Medicine, School of Medicine, University of São Paulo, São Paulo, Brazil
Interests: host-parasite interaction in paracoccidioidomycosis; clinical classification and management of paracoccidioidomycosis
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Proteomics Center, Mycology Laboratory, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista (UNESP), Araraquara, SP, Brazil
Interests: histoplasmosis; paracoccidioidomycosis; virulence; biofilm; molecular biology
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Special Issue Information

Dear Colleagues,

The Special Issue entitled "New Perspectives on Filamentous and Dimorphic Fungi Research" aims to present recent research on any aspect of the filamentous and dimorphic fungi that may cause invasive mycoses associated with high mortality rates. Fungal infections present complex epidemiology, risk factors, globally variable distribution, and ultimately antifungal resistance. Among filamentous fungi, Aspergillus spp, Fusarium spp., Mucorales, Lomentospora prolificans, and Scedosporium spp. are the most important due to the mortality rate, antifungal resistance, and challenges in timely diagnosis and treatment. Dimorphic fungi are a group of fungal pathogens that occupy a specific ecological niche in the environment, and most belong to Ajellomycetaceae, a family that currently comprises the genera Blastomyces, Emmonsia, Emmonsiellopsis, Histoplasma, Coccidioides, Lacazia, and Paracoccidioides, whereas Sporothrix spp. belong to the family Ophiostomataceae.

On the other hand, talaromycosis (Penicilliosis) is an opportunistic mycosis caused by the thermally dimorphic fungus Talaromyces (Penicillium) marneffei. Fungal pathogen distribution and epidemiology vary significantly by region: some are global, while others are endemic to certain areas. Like other significant causes of systemic mycoses, the extent of disease and outcomes result from complex interactions between these human pathogens and the host's immune response.

Therefore, this Special Issue's topics include, but are not limited to: aspects of taxonomy, epidemiology and climate change; virulence factors; molecular identification, immunopathology; host–pathogen interactions; new experimental models; laboratory diagnosis; clinical aspects; and current treatment.

Any reviews, original research, and communications will be welcome.

Prof. Dr. Maria Mendes Giannini
Prof. Dr. Angel Gonzalez Marin
Prof. Dr. Gil Benard
Dr. Ana Marisa Fusco Almeida
Guest Editors

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Published Papers (1 paper)

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Research

18 pages, 2182 KiB  
Article
Generation, Transfer, and Loss of Alternative Oxidase Paralogues in the Aspergillaceae Family
by Michel Flipphi, Alexandra Márton, Vivien Bíró, Norbert Ág, Erzsébet Sándor, Erzsébet Fekete and Levente Karaffa
J. Fungi 2023, 9(12), 1195; https://doi.org/10.3390/jof9121195 - 14 Dec 2023
Viewed by 1460
Abstract
Alternative oxidase (Aox) is a terminal oxidase operating in branched electron transport. The activity correlates positively with overflow metabolisms in certain Aspergilli, converting intracellular glucose by the shortest possible path into organic acids, like citrate or itaconate. Aox is nearly ubiquitous in [...] Read more.
Alternative oxidase (Aox) is a terminal oxidase operating in branched electron transport. The activity correlates positively with overflow metabolisms in certain Aspergilli, converting intracellular glucose by the shortest possible path into organic acids, like citrate or itaconate. Aox is nearly ubiquitous in fungi, but aox gene multiplicity is rare. Nevertheless, within the family of the Aspergillaceae and among its various species of industrial relevance—Aspergillus niger, A. oryzae, A. terreus, Penicillium rubens—paralogous aox genes coexist. Paralogous genes generally arise from duplication and are inherited vertically. Here, we provide evidence of four independent duplication events along the lineage that resulted in aox paralogues (aoxB) in contemporary Aspergillus and Penicillium taxa. In some species, three aox genes are co-expressed. The origin of the A. niger paralogue is different than that of the A. terreus paralogue, but all paralogous clades ultimately arise from ubiquitous aoxA parent genes. We found different patterns of uncorrelated gene losses reflected in the Aspergillus pedigree, albeit the original aoxA orthologues persist everywhere and are never replaced. The loss of acquired paralogues co-determines the contemporary aox gene content of individual species. In Aspergillus calidoustus, the two more ancient paralogues have, in effect, been replaced by two aoxB genes of distinct origins. Full article
(This article belongs to the Special Issue New Perspectives on Filamentous and Dimorphic Fungi Research)
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