Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.9
4.7
Journals
JoF
Special Issues
Invasive Fungal Diseases in Hospitalized Patients
share announcement

Invasive Fungal Diseases in Hospitalized Patients

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: closed (1 August 2023) | Viewed by 4300

Special Issue Editor

Prof. Dr. Ivana Mareković

E-Mail Website
Guest Editor
Clinical Department of Clinical Microbiology, Infection and Prevention Control, University Hospital Centre Zagreb, 10 000 Zagreb, Croatia
Interests: immunocompromised patients; healthcare-associated infections; candidemia; invasive aspergillosis; fungal biomarkers

Special Issue Information

Dear Colleagues,

Invasive fungal diseases are becoming more common in healthcare settings as medical research and technology advance. Namely, hospitalized patients are facing invasive procedures (intensive care for critically ill patients, solid organ and hematopoietic stem cell transplantation)  and a growing number of different imunosuppresive drugs (anticancer treatment, biologic therapy) are necessary for their underlying condition management, but they are also predisposed to invasive fungal diseases. The common characteristic for all invasive fungal diseases is difficulty in establishing a diagnosis. Therefore, early empiric therapy and/or prohylaxis in high-risk patients is crucial. This Special Issue entitled "Invasive Fungal Diseases in Hospitalized Patients" aims to present current findings on any aspect of the epidemiology including risk factors, diagnostic testing, and management of invasive fungal diseases in hospitalized patients. The objective is to provide an up-to-date picture of these infections, motivate researchers including physicians to reflect on their experiments as well as routine patient cases, and encourage them to share their knowledge to help these patients be managed better. Original research, reviews, and communications are all welcome.

Prof. Dr. Ivana Mareković
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • healthcare-associated infections
  • Candida spp.
  • Cryptococcus spp.
  • Aspergillus spp.
  • Fusarium spp.
  • Mucorales
  • Scedosporium spp.
  • galactomannan
  • beta-D-glucan
  • antifungal treatment

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

13 pages, 329 KiB  
Article
Clinical, Epidemiological and Laboratory Features of Invasive Candida parapsilosis Complex Infections in a Brazilian Pediatric Reference Hospital during the COVID-19 Pandemic
by Paulo Henrique Peixoto, Maria Laína Silva, Fernando Victor Portela, Bruno da Silva, Edlâny Milanez, Denis de Oliveira, Aldaíza Ribeiro, Henrique de Almeida, Reginaldo Lima-Neto, Glaucia Morgana Guedes, Débora Castelo-Branco and Rossana Cordeiro
J. Fungi 2023, 9(8), 844; https://doi.org/10.3390/jof9080844 - 13 Aug 2023
Viewed by 1678
Abstract
The present study aimed to describe the clinical, epidemiological and laboratory characteristics of invasive candidiasis by C. parapsilosis complex (CPC) in a Brazilian tertiary pediatric hospital during the COVID-19 pandemic. Clinical samples were processed in the BACT/ALERT® 3D system or on agar [...] Read more.
The present study aimed to describe the clinical, epidemiological and laboratory characteristics of invasive candidiasis by C. parapsilosis complex (CPC) in a Brazilian tertiary pediatric hospital during the COVID-19 pandemic. Clinical samples were processed in the BACT/ALERT® 3D system or on agar plates. Definitive identification was achieved by MALDI-TOF MS. Antifungal susceptibility was initially analyzed by the VITEK 2 system (AST-YS08 card) and confirmed by the CLSI protocol. Patient data were collected from the medical records using a structured questionnaire. CPC was recovered from 124 patients over an 18-month period, as follows: C. parapsilosis (83.87%), C. orthopsilosis (13.71%) and C. metapsilosis (2.42%). Antifungal resistance was not detected. The age of the patients with invasive CPC infections ranged from <1 to 18 years, and most of them came from oncology-related sectors, as these patients were more affected by C. parapsilosis. C. orthopsilosis infections were significantly more prevalent in patients from critical care units. Invasive infections caused by different pathogens occurred in 75 patients up to 30 days after the recovery of CPC isolates. Overall, 23 (18.55%) patients died within 30 days of CPC diagnosis. Catheter removal and antifungal therapy were important measures to prevent mortality. COVID-19 coinfection was only detected in one patient. Full article
(This article belongs to the Special Issue Invasive Fungal Diseases in Hospitalized Patients)

Review

Jump to: Research

42 pages, 658 KiB  
Review
Outbreaks of Fungal Infections in Hospitals: Epidemiology, Detection, and Management
by Abby P. Douglas, Adam G. Stewart, Catriona L. Halliday and Sharon C.-A. Chen
J. Fungi 2023, 9(11), 1059; https://doi.org/10.3390/jof9111059 - 29 Oct 2023
Cited by 1 | Viewed by 2299
Abstract
Nosocomial clusters of fungal infections, whilst uncommon, cannot be predicted and are associated with significant morbidity and mortality. Here, we review reports of nosocomial outbreaks of invasive fungal disease to glean insight into their epidemiology, risks for infection, methods employed in outbreak detection [...] Read more.
Nosocomial clusters of fungal infections, whilst uncommon, cannot be predicted and are associated with significant morbidity and mortality. Here, we review reports of nosocomial outbreaks of invasive fungal disease to glean insight into their epidemiology, risks for infection, methods employed in outbreak detection including genomic testing to confirm the outbreak, and approaches to clinical and infection control management. Both yeasts and filamentous fungi cause outbreaks, with each having general and specific risks. The early detection and confirmation of the outbreak are essential for diagnosis, treatment of affected patients, and termination of the outbreak. Environmental sampling, including the air in mould outbreaks, for the pathogen may be indicated. The genetic analysis of epidemiologically linked isolates is strongly recommended through a sufficiently discriminatory approach such as whole genome sequencing or a method that is acceptably discriminatory for that pathogen. An analysis of both linked isolates and epidemiologically unrelated strains is required to enable genetic similarity comparisons. The management of the outbreak encompasses input from a multi-disciplinary team with epidemiological investigation and infection control measures, including screening for additional cases, patient cohorting, and strict hygiene and cleaning procedures. Automated methods for fungal infection surveillance would greatly aid earlier outbreak detection and should be a focus of research. Full article
(This article belongs to the Special Issue Invasive Fungal Diseases in Hospitalized Patients)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop