Dysautonomia, Inflammaging, and Chronic Diseases
A Special Issue of Journal of Gerontology and Geriatrics (ISSN 2499-6564) belonging to the section "Translational Sciences".
Deadline for manuscript submissions: 30 April 2027 | Viewed by 1695
Editors
Interests: autonomic nervous system; cardiovascular physiology; inflammation; neuroimmune interactions; chronic disease pathophysiology
Special Issues, Collections and Topics in MDPI journals
Interests: pneumology; geriatrics; internal medicine; heart failure; nutrition
2. Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy
Interests: biogerontology; longevity; age-related diseases; frailty; inflammaging; centenarians
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autonomic nervous system (ANS) dysfunction and chronic low-grade inflammation are increasingly recognized as common pathophysiological threads linking multiple chronic diseases, including cardiovascular, metabolic, neurodegenerative, and geriatric syndromes. The concept of “inflammaging” has emerged as a key driver of morbidity and mortality in older adults. Concurrently, dysautonomia (e.g., orthostatic intolerance, heart rate variability alterations, and baroreflex impairment) frequently coexists with inflammaging and may both contribute to and result from chronic inflammatory states. Despite growing evidence, the bidirectional relationship between autonomic dysfunction and inflammaging remains underexplored, and therapeutic strategies targeting this crosstalk are still in early stages. This Special Issue aims to bridge that gap by gathering cutting-edge research on the intersection of dysautonomia, inflammaging, and chronic diseases.
This Special Issue aims to compile original research and review articles that elucidate the mechanisms, clinical manifestations, diagnostic approaches, and potential treatments linking autonomic nervous system dysfunction with inflammaging across the spectrum of chronic non-communicable diseases. The topic fits well within the journal’s scope, as it addresses fundamental physiology, pathophysiology, translational medicine, and clinical aspects of aging and chronic disease management. By focusing on integrative physiology and multisystem interactions, this issue will appeal to physiologists, geriatricians, neurologists, cardiologists, immunologists, and clinical researchers.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Autonomic regulation of immune function and inflammation;
- Heart rate variability as a biomarker of inflammaging in chronic diseases;
- Dysautonomia in metabolic syndrome, diabetes, and obesity;
- Inflammaging and autonomic dysfunction in neurodegenerative disorders (Parkinson’s, Alzheimer’s);
- Autonomic–immune crosstalk in cardiovascular diseases;
- Nutritional, lifestyle, and pharmacological interventions targeting both dysautonomia and inflammaging;
- Aging-related autonomic decline and its inflammatory consequences;
- Role of the gut–brain axis and microbiome in autonomic–inflammatory pathways;
- Novel diagnostic tools and biomarkers for combined autonomic-inflammatory assessment.
We look forward to receiving your contributions.
Dr. Gabriel Dias Rodrigues
Dr. Diana Lelli
Dr. Beatrice Arosio
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Gerontology and Geriatrics is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- dysautonomia
- inflammaging
- autonomic nervous system
- chronic inflammation
- aging
- heart rate variability
- chronic disease
- neurodegeneration
- cardiovascular disease
- immuno-physiology
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
