Special Issue "Cell Fate Decisions in Development and Disease"
A special issue of Journal of Developmental Biology (ISSN 2221-3759).
Deadline for manuscript submissions: closed (30 September 2015).
Interests: cell-fate determination; cell lineage; organ development; fibrotic disease
Special Issues and Collections in MDPI journals
All cells are descended from progenitors. In development, the differentiation of progenitor cells provides a mechanism through which cellular diversity and specialization can be achieved. Furthermore, in recent years, we have discovered that most tissues set aside undifferentiated progenitors that likely play a role in the homeostasis of the tissue throughout life. The differentiation of these cells during homeostasis is likely a highly regulated process. In disease, the growth and differentiation of progenitors may become dysregulated, but this is poorly understood. For example, the cancer stem cell hypothesis suggests that malignant tumors are derived from populations of tumor cells that share similar biologic properties to normal adult stem cells. These could be endogenous stems cells that, over time, have accumulated somatic mutations that cause malignancy. Another example is in fibrosis, where there is an accumulation of myofibroblasts that secrete extracellular matrix elements that make tissues non-compliant. Very little is understood about the sources of myofibroblasts in fibrotic tissues, but it was long believed that these cells were derived from local sources. Is this true? This Special Issue of the Journal of Developmental Biology welcomes submissions on any area of cell fate decisions in development and disease. This can include new insights on mechanisms that control cell fate differentiation, methods that can be employed to study and quantify cell fate differentiation, and reviews of what is known about how cell fate differentiation goes awry in disease or disease models.
Dr. Robert W. Dettman
- cell fate
- cell lineage
- stem cells
- cancer stem cell
- neuronal stem cell
- bone marrow