Special Issue "Diabetic Cardiomyopathy "

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425).

Deadline for manuscript submissions: 1 August 2020.

Special Issue Editor

Guest Editor
Dr. Óscar Lorenzo González

Universidad Autonoma de Madrid, School of Medicine, Madrid, Spain
Website | E-Mail
Phone: 0034 687224330
Interests: diabetes; obesity; cardiomyopathy

Special Issue Information

Dear Colleagues,

Nowadays, obesity is seriously increasing in most of the populations all over the world, and is associated with the development and progression of high-mortality diseases, such as type-2 diabetes mellitus (T2DM) and its subsequent cardiovascular pathologies. In this sense, diabetic cardiomyopathy (DCM) is a cardiac dysfunction, which affects approximately 12% of diabetic patients, leading to overt heart failure and death. DCM is defined by functional and structural changes at the myocardium, independent of any vascular or cardiac disease. However, there is not an efficient and specific methodology for DCM diagnosis, possibly because molecular mechanisms are not fully elucidated, and it remains asymptomatic for many years. In addition, DCM frequently coexists with other comorbidities such as hypertension, obesity, dyslipidemia, and vasculopathies. In this regard, besides imaging techniques, quantification of specific plasma biomarkers related to initial responses, such as cardiac hypertrophy, stiffness and steatosis, may be convenient. In addition, the rising prevalence and accumulating costs of cardiovascular disease in obese and T2DM patients underscore the deficiencies of tertiary prevention and call for a shift in medical treatment. Effective prevention and treatment of DCM may require measures to regulate the metabolic derangement occurring in the heart, rather than merely restoring suitable systemic parameters. Recent research has provided deeper insight into the metabolic etiology of DCM and numerous heart-specific targets that may substitute or reinforce current strategies. Thus, efforts must focus on the need for prospective metabolic targets that may avert myocardial vulnerability and functional decline in next-generation diabetic care.

Dr. Óscar Lorenzo González
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Diabetes
  • Obesity
  • Cardiomyopathy
  • Mitochondria Dysfunction
  • Cardiac Metabolism
  • Diagnosis
  • Prognosis
  • Biomarkers
  • Incretin
  • Metformin

Published Papers (2 papers)

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Review

Open AccessReview
Cardiovascular Risks Associated with Gender and Aging
J. Cardiovasc. Dev. Dis. 2019, 6(2), 19; https://doi.org/10.3390/jcdd6020019
Received: 28 March 2019 / Revised: 19 April 2019 / Accepted: 23 April 2019 / Published: 27 April 2019
Cited by 1 | PDF Full-text (1154 KB) | HTML Full-text | XML Full-text
Abstract
The aging and elderly population are particularly susceptible to cardiovascular disease. Age is an independent risk factor for cardiovascular disease (CVD) in adults, but these risks are compounded by additional factors, including frailty, obesity, and diabetes. These factors are known to complicate and [...] Read more.
The aging and elderly population are particularly susceptible to cardiovascular disease. Age is an independent risk factor for cardiovascular disease (CVD) in adults, but these risks are compounded by additional factors, including frailty, obesity, and diabetes. These factors are known to complicate and enhance cardiac risk factors that are associated with the onset of advanced age. Sex is another potential risk factor in aging adults, given that older females are reported to be at a greater risk for CVD than age-matched men. However, in both men and women, the risks associated with CVD increase with age, and these correspond to an overall decline in sex hormones, primarily of estrogen and testosterone. Despite this, hormone replacement therapies are largely shown to not improve outcomes in older patients and may also increase the risks of cardiac events in older adults. This review discusses current findings regarding the impacts of age and gender on heart disease. Full article
(This article belongs to the Special Issue Diabetic Cardiomyopathy )
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Open AccessReview
Non-Invasive Imaging in Diabetic Cardiomyopathy
J. Cardiovasc. Dev. Dis. 2019, 6(2), 18; https://doi.org/10.3390/jcdd6020018
Received: 5 March 2019 / Revised: 11 April 2019 / Accepted: 15 April 2019 / Published: 16 April 2019
PDF Full-text (1330 KB) | HTML Full-text | XML Full-text
Abstract
There is increasing recognition of a specific diabetic cardiomyopathy beyond ischemic cardiomyopathy, which leads to structural and functional myocardial abnormalities. The aim of this review is to summarize the recent literature on diagnostic findings and prognostic significance of non-invasive imaging including echocardiography, nuclear [...] Read more.
There is increasing recognition of a specific diabetic cardiomyopathy beyond ischemic cardiomyopathy, which leads to structural and functional myocardial abnormalities. The aim of this review is to summarize the recent literature on diagnostic findings and prognostic significance of non-invasive imaging including echocardiography, nuclear imaging, computed tomography and cardiovascular magnetic resonance in diabetic cardiomyopathy. Full article
(This article belongs to the Special Issue Diabetic Cardiomyopathy )
Figures

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J. Cardiovasc. Dev. Dis. EISSN 2308-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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