Structure–Activity Relationship in Transition Metal Complexes for Medicine and Catalysis
A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 68
Special Issue Editors
Interests: transition metal complexes; structure–activity relationship (SAR); bioinorganic chemistry; vanadium antidiabetic complexes; ruthenium anticancer complexes; copper antimicrobial complexes; metal–biomolecule interactions (DNA, proteins, enzymes); medicinal inorganic chemistry
Interests: X-ray crystallography; supramolecular biomimetic chemistry; calixarene-based recognition of DNA/RNA; coordination chemistry of transition metals; biomolecular crystallization; structural chemistry of supramolecular systems
Special Issue Information
Dear Colleagues,
In the current era of rapid progress in the development of new therapeutic agents and catalysts, transition metal complexes occupy a central role. Their unique structural and electronic properties enable functions that cannot be achieved with purely organic molecules. From the early development of platinum-based anticancer drugs and vanadium antidiabetic activity to the discovery of highly selective catalytic systems, the ability of transition metals to interact with biomolecules and mediate chemical transformations has placed them at the forefront of modern inorganic and bioinorganic chemistry.
Understanding the relationship between molecular structure and functional outcome is essential for advancing this field. Rational design, along with variations in ligand frameworks, coordination environments, oxidation states, or geometries, can profoundly influence biological activity, catalytic reactivity, and selectivity. Exploring these structure–activity relationships opens the way for the design of new complexes with optimized pharmacological potential or enhanced catalytic efficiency.
In this Special Issue, we aim to gather contributions that highlight fundamental and applied studies in this area, ranging from the synthesis and structural characterization of novel metal complexes to investigations of their interactions with biomolecules, mechanistic studies of enzyme inhibition or activation, and the development of catalytic systems relevant to sustainable chemistry. Both original research articles and focused critical reviews are welcome, with the shared goal of illuminating how molecular design translates into function in transition metal complexes.
Dr. Adnan Zahirovic
Dr. Aleksandar Višnjevac
Guest Editors
Manuscript Submission Information
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Keywords
- transition metal complexes
- structure–activity relationship (SAR)
- spectroscopy and structural characterization
- metal-based drugs
- catalysis
- biomolecule interactions
- computational modeling
- mechanistic studies
- biological activity
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