Advanced Retrieval-Augmented Generation Systems Based on Large Language Models

A special issue of Information (ISSN 2078-2489). This special issue belongs to the section "Artificial Intelligence".

Deadline for manuscript submissions: 15 February 2026 | Viewed by 365

Special Issue Editors


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Guest Editor
Department of Applied Computing, University of Zagreb Faculty of Electrical Engineering and Computing, Zagreb, Croatia
Interests: artificial intelligence; natural language processing; machine learning

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Guest Editor
Institute for Cognitive Sciences and Technologies, National Research Council, 00185 Rome, Italy
Interests: ontology engineering; linked data; semantic web; knowledge extraction; natural language understanding

Special Issue Information

Dear Colleagues,

We invite researchers, academics, and practitioners to contribute to this Special Issue focused on advanced retrieval-augmented generation (RAG) systems powered by large language models (LLMs). This issue aims to explore cutting-edge methodologies and solutions that leverage LLMs to enhance information retrieval, knowledge generation, and decision-making processes across various domains. Key topics include the following:

  • Advanced techniques for integrating LLMs into RAG systems to improve accuracy, efficiency, and scalability.
  • Cross-domain applications of RAG systems powered by LLMs, including healthcare, legal tech, education, and finance.
  • Novel approaches to fine-tuning LLMs for specialized retrieval tasks and domain-specific knowledge bases.
  • Comparative studies and evaluations of LLM-based RAG systems versus traditional or hybrid approaches.
  • Ethical, legal, and societal implications of deploying LLMs in RAG systems, including considerations of bias, fairness, and transparency.

We welcome submissions presenting original research, case studies, and theoretical advancements, addressing both technical and practical aspects of LLM-driven RAG systems.

Dr. Marina Bagic Babac
Dr. Andrea Giovanni Nuzzolese
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Information is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • retrieval-augmented generation (RAG)
  • large language models (LLMs)
  • information retrieval
  • knowledge generation
  • decision making
  • cross-domain applications

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Published Papers (1 paper)

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Research

24 pages, 3421 KiB  
Article
Cloud-Based Medical Named Entity Recognition: A FIT4NER-Based Approach
by Philippe Tamla, Florian Freund and Matthias Hemmje
Information 2025, 16(5), 395; https://doi.org/10.3390/info16050395 - 12 May 2025
Viewed by 204
Abstract
This paper presents a cloud-based system that builds upon the FIT4NER framework to support medical experts in training machine learning models for named entity recognition (NER) using Microsoft Azure. The system is designed to simplify complex cloud configurations while providing an intuitive interface [...] Read more.
This paper presents a cloud-based system that builds upon the FIT4NER framework to support medical experts in training machine learning models for named entity recognition (NER) using Microsoft Azure. The system is designed to simplify complex cloud configurations while providing an intuitive interface for managing and converting large-scale training and evaluation datasets across formats such as PDF, DOCX, TXT, BioC, spaCyJSON, and CoNLL-2003. It also enables the configuration of transformer-based spaCy pipelines and orchestrates Azure cloud services for scalable and efficient NER model training. Following the structured Nunamaker research methodology, the paper introduces the research context, surveys the state of the art, and highlights key challenges faced by medical professionals in cloud-based NER. It then details the modeling, implementation, and integration of the system. Evaluation results—both qualitative and quantitative—demonstrate enhanced usability, scalability, and accessibility for non-technical users in medical domains. The paper concludes with insights gained and outlines directions for future work. Full article
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