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Advances in Telomeres and Interstitial Telomeric Sequences

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 225

Special Issue Editor


E-Mail Website
Guest Editor
Laboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia
Interests: telomeric repeats; telomeres; genome stability; microsatellites; repeat expansion; alternative lengthening of telomeres

Special Issue Information

Dear Colleagues,

Telomeres are nucleoprotein structures protecting ends of chromosomes from degradation and end-to-end fusions. Telomeres play an essential role in many aspects of cell metabolism. For example, they are one of the key regulators of cell proliferation potential, and their length correlates inversely with age in somatic cells. The maintenance of telomeres is essential for actively dividing cells. It is known that the length of telomeres can be maintained via telomerase, or via mechanisms independent of the action of telomerase, which are called alternative lengthening of telomeres (ALT). The activation of telomerase, or ALT, is a prerequisite for cancer development. Microsatellite TTAGGG repeats are the building blocks of telomeres in vertebrates. Interestingly, tracts of telomeric repeats are not found exclusively at the ends of chromosomes. In fact, they are present in multiple internal sites of chromosomes in many species, including humans. Such sequences are called interstitial telomeric sequences (ITSs). The functions of ITSs in the genome are still enigmatic. They are thought to be involved in interactions with telomeres and shape the 3D genome structure. Such sequences are unstable and may stimulate mutagenesis, provoke chromosomal rearrangements, and undergo spontaneous length alterations (contractions and expansions).

This Special Issue focuses (i) on the role that telomeres and ITSs play in the organization, stability, and evolution of the genome in normal and pathological conditions, as well as (ii) on various aspects of the maintenance and dynamics of telomeric sequences (at both telomeres and internal chromosomal sites).

Dr. Anna Y Aksenova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • telomeres
  • telomerase
  • interstitial telomeric sequences
  • alternative lengthening of telomeres
  • genome instability
  • aging
  • cancer

Published Papers

This special issue is now open for submission.
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