Recent Advances in Immunobiology in Colorectal Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 461
Special Issue Editor
Special Issue Information
Dear Colleagues,
Recently, the prevalence of colorectal cancer (CRC) has been increasing worldwide; fatalities have increased by more than 30% over the past 15 years, and are expected to increase by 25% over the next 10 years despite advances in surgical techniques, radiotherapy, chemotherapy and molecular-targeted drugs.
Accumulating evidence has revealed that the various types of immune cells, including macrophages and neutrophils, as components of the tumor microenvironment (TME) contribute to the progression of CRCs. The interaction between CRC cells and immune cells through the inflammatory cytokines and chemokines contributes to the acceleration of the proliferation and migration of CRC cells. These immune cells surrounding CRC cells have been highlighted as novel biomarkers, prognostic predictors and therapeutic targets. Enhanced understanding of immunobiology could lead to the improved management of CRCs with novel diagnosis, prognosis prediction, prevention and treatment.
In this Special Issue, we invite your contributions, in the form of original research articles, reviews, or shorter perspective articles on all aspects related to the theme of “Immunobiology in Colorectal Cancer”.
Dr. Rei Mizuno
Guest Editor
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Keywords
- colorectal cancers (CRCs)
- immune cells
- tumor environment (TME)
- immunotherapy
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