New Insights into DNA Modifications in Urine
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 January 2024) | Viewed by 293
Special Issue Editor
Interests: cancer biology; biochemistry; DNA repair; antioxidant activity; oxidative stress; epigenetics
Special Issue Information
Dear Colleagues,
Changes in the structure of DNA may be associated with physiological processes occurring in the cell, such as methylation and demethylation, or with disorders leading to damage. DNA lesions can be generated by environmental factors as well as endogenous causes resulting from malfunctioning repair systems and antioxidant defense. DNA damages are potentially mutagenic and can lead to the development of pathological processes. Repair systems are needed to remove modified nucleobases and nucleosides from DNA, and eliminated modifications are released into the bloodstream and eventually also appear in the urine. Therefore, measurement of urinary excretion of lesions can reflect DNA damage on the level of the whole body. Furthermore, the noninvasiveness of the urinary analysis allows for its application to large-scale basic research and clinical studies.
This Special Issue is focused on the role of urinary DNA lesions and modifications in physiological and pathological conditions and their potential usefulness as biomarkers. The determination of DNA modifications in urine may be an attractive noninvasive diagnostic option, so research articles on novel methods of analysis are also invited.
Dr. Rafal Rozalski
Guest Editor
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Keywords
- DNA modifications
- biomarkers
- DNA damage and repair
- oxidative stress
- DNA lesions
- human diseases
- epigenetic modifications
- urine
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