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The Fascinating World of Lithium
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The Fascinating World of Lithium

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Science and Engineering".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 17158

Special Issue Editors

Dr. Maria Orquídia Teixeira Neves

E-Mail Website1 Website2
Guest Editor
1) Department of Civil Engineering, Architecture and Georesources, Instituto Superior Técnico, University of Lisbon, 1041-001 Lisbon, Portugal
2) CERENA (Centro de Recursos Naturais e Ambiente), 1041-001 Lisbon, Portugal
Interests: medical geology; water health benefits; exposure assessment; water-soils-plants quality; biomarkers; mineral resources; environmental pollution
Dr. José Manuel Marques

E-Mail Website1 Website2
Guest Editor
1. Department of Mineral and Energy Resources Engineering, Instituto Superior Técnico, University of Lisbon, 1049-001 Lisbon, Portugal
2. Centro de Recursos Naturais e Ambiente (CERENA), Instituto Superior Técnico, University of Lisbon, 1049-001 Lisbon, Portugal
Interests: isotope hydrology; hydrogeology; water-rock interaction; thermal and mineral waters; geothermal resources; groundwater pollution and protection
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Lithium, which occurs widely in nature, generally in trace concentrations, has been in the list of Critical Raw Materials since September 2020.

The peculiarities of lithium give it important properties that make it useful in many areas, such as the nuclear industry, industrial production processes, high-tech applications (e.g., ultra-large telescope optics), military applications, earth science process studies (e.g., geochronometers, weathering thermostats), medicine (e.g., treatment of psychiatric affective disorders), and emerging clean and alternative energies (e.g., rechargeable batteries) for electric mobility. In both lithium applications and lithium extraction and innovative and sustainable technologies, we can expect major changes to occur in the near future. Progress towards lithium recovery and waste recycling and understanding the mechanism by which lithium exerts its effects on the human body are other challenges to be overcome in the future.

Since lithium has, for a long time, played an important role in society, we invite colleagues from different disciplines to share their research on Li geological resources and economic exploitation, fields of application, future demands, environmental concerns, biochemistry mechanisms, and human health.

For this Special Issue of the International Journal of Environmental Research and Public Health (IJERPH), original research papers, reviews, case reports, and conference papers are welcome.

Dr. Maria Orquídia Teixeira Neves
Prof. Dr. José Manuel Marques
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • lithium
  • Earth processes
  • natural resources
  • industrial applications
  • energy transition
  • recovery and recycling
  • waters and soils
  • food chain
  • biomonitoring
  • mental health

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Published Papers (4 papers)

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Research

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9 pages, 340 KB  
Article
Hemodialysis Treatment for Patients with Lithium Poisoning
by Yu-Hsin Liu, Kai-Fan Tsai, Pai-Chin Hsu, Meng-Hsuan Hsieh, Jen-Fen Fu, I-Kuan Wang, Shou-Hsuan Liu, Cheng-Hao Weng, Wen-Hung Huang, Ching-Wei Hsu and Tzung-Hai Yen
Int. J. Environ. Res. Public Health 2022, 19(16), 10044; https://doi.org/10.3390/ijerph191610044 - 15 Aug 2022
Cited by 5 | Viewed by 4685
Abstract
Background: Hemodialysis is often recommended to treat severe lithium poisoning. Nevertheless, the application rate of hemodialysis in patients with lithium poisoning is varied across different groups and the effect of hemodialysis is still undetermined. Therefore, this study aimed to analyze the hemodialysis rate [...] Read more.
Background: Hemodialysis is often recommended to treat severe lithium poisoning. Nevertheless, the application rate of hemodialysis in patients with lithium poisoning is varied across different groups and the effect of hemodialysis is still undetermined. Therefore, this study aimed to analyze the hemodialysis rate of patients with lithium poisoning and to explore the clinical features of lithium-poisoned-patients treated or untreated with hemodialysis. Methods: Between 2001 and 2019, 36 patients treated at the Chang Gung Memorial Hospital for the management of lithium poisoning were stratified according to whether they were treated with hemodialysis (n = 7) or not (n = 29). Results: The patients were aged 50.7 ± 18.1 years. The poisoning patterns were acute on chronic (61.1%), chronic (25.0%) and acute (13.9%). The precipitating factors of dehydration and infection were noted in 36.1% and 25.0% of patients, respectively. Bipolar disorder (72.2%), depressive disorder (27.8%) and psychotic disorder (11.1%) were the top three psychiatric comorbidities. The hemodialysis group not only had a lower Glasgow Coma Scale (GCS) score (p = 0.001) but also had a higher respiratory failure rate (p = 0.033), aspiration pneumonia rate (p = 0.033) and acute kidney injury network (AKIN) score (p = 0.002) than the non-hemodialysis group. Although none of the patients died of lithium poisoning, the hemodialysis group required more endotracheal intubation (p = 0.033), more intensive care unit admission (p = 0.033) and longer hospitalization (p = 0.007) than the non-hemodialysis group. Conclusion: The analytical results revealed zero mortality rate and low hemodialysis rate (1.9%). Compared with patients without hemodialysis, patients receiving hemodialysis suffered severer lithium-associated complications and needed a more intensive care unit admission and longer hospital stay. Full article
(This article belongs to the Special Issue The Fascinating World of Lithium)

Review

Jump to: Research, Other

9 pages, 310 KB  
Review
The Present State of Lithium for the Prevention of Dementia Related to Alzheimer’s Dementia in Clinical and Epidemiological Studies: A Critical Review
by Nobuyoshi Ishii, Takeshi Terao and Hirofumi Hirakawa
Int. J. Environ. Res. Public Health 2021, 18(15), 7756; https://doi.org/10.3390/ijerph18157756 - 22 Jul 2021
Cited by 17 | Viewed by 8159
Abstract
Despite the unavailability of essential anti-dementia drugs, lithium may inhibit glycogen synthase kinase-3 (GSK-3) and decrease beta-amyloid and hyper-phosphorylated tau. In this review, we hypothesized that trace to standard levels of lithium (i.e., corresponding to the therapeutic levels for bipolar disorder) may be [...] Read more.
Despite the unavailability of essential anti-dementia drugs, lithium may inhibit glycogen synthase kinase-3 (GSK-3) and decrease beta-amyloid and hyper-phosphorylated tau. In this review, we hypothesized that trace to standard levels of lithium (i.e., corresponding to the therapeutic levels for bipolar disorder) may be effective for dementia prevention. Excluding three insufficient level studies, we obtained two and one excellent clinical studies on standard and trace lithium levels, respectively, all of which supported the effects of lithium for dementia prevention. In addition, we identified good clinical and epidemiological studies (four each) on standard lithium levels, of which six studies supported the effects of lithium. Moreover, of three good epidemiological studies on trace lithium levels, two supported the aforementioned effects of lithium. The number of studies were substantially small, particularly those on trace lithium levels. Moreover, studies on standard lithium levels were insufficient to establish the efficacy of lithium for dementia prevention. This necessitates accumulating good or excellent clinical evidence for the effects of trace to standard lithium levels on dementia prevention. Full article
(This article belongs to the Special Issue The Fascinating World of Lithium)

Other

Jump to: Research, Review

2 pages, 265 KB  
Reply
Reply to Ott, M.; Werneke, U. Comment on “Liu et al. Hemodialysis Treatment for Patients with Lithium Poisoning. Int. J. Environ. Res. Public Health 2022, 19, 10044”
by Yu-Hsin Liu and Tzung-Hai Yen
Int. J. Environ. Res. Public Health 2023, 20(11), 5951; https://doi.org/10.3390/ijerph20115951 - 25 May 2023
Viewed by 1358
Abstract
We would like to thank Professor Ott and Professor Werneke for their helpful comments [...] Full article
(This article belongs to the Special Issue The Fascinating World of Lithium)
2 pages, 657 KB  
Comment
Comment on Liu et al. Hemodialysis Treatment for Patients with Lithium Poisoning. Int. J. Environ. Res. Public Health 2022, 19, 10044
by Michael Ott and Ursula Werneke
Int. J. Environ. Res. Public Health 2023, 20(10), 5843; https://doi.org/10.3390/ijerph20105843 - 17 May 2023
Cited by 2 | Viewed by 1890
Abstract
In a recent article, Liu and colleagues presented a case-series of patients with lithium poisoning, with special emphasis on hemodialysis [...] Full article
(This article belongs to the Special Issue The Fascinating World of Lithium)
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