E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Special Issue "Endocrine Disruptor, Exposure and Potential Health Impact"

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Health".

Deadline for manuscript submissions: 31 July 2019

Special Issue Editor

Guest Editor
Assoc. Prof. Dr. Jiangang Chen

Department of Public Health, College of Education, Health, and Human Sciences, The University of Tennessee, Knoxville, TN, USA
Website | E-Mail
Interests: Endocrine Disruptors; Early Life Exposure; Reproductive Toxicology; Gut Microbiota and Susceptibility to Pathogen Infection

Special Issue Information

Dear Colleagues,

There is a growing public concern regarding the potential health impact of endocrine disrupting chemicals (EDCs) exposure from the environment. First coined in the early 1990s, EDCs are characterized as a group of exogenous chemicals that target various components of the endocrine system. The existence of EDCs in our daily life is ubiquitous, and the sources of EDC exposure are diverse. EDC disrupts the homeostasis of an endogenous system through multiple mechanisms, acting as a mimic or antagonist on classic nuclear receptors and membrane associated receptors. They may also interfere with the synthesis and function of critical enzymes in a specific endocrine system. Initial research efforts on EDCs were primarily focused on reproductively-relevant health risks. The scope of recent research has further expanded to delve into the consequence of transgenerational exposure, epigenetic effects, neurological and behavioral changes, and the potential link of EDC exposure to metabolic disorders.

This Special Issue seeks original research papers on various aspects of EDCs, from their detection in various environment/biological matrices to the adverse consequences of their exposure. In particular, we encourage the submission of research that focuses on issues related to EDC exposure on the development of critical systems, including but not limited to endocrine, neurological, reproductive, metabolic, and immune systems. We also encourage the submission of original research works on the impact of low-level EDC exposure, exposure to EDC mixtures, early life exposure, the identification of novel EDCs, and multigenerational studies that are designed to understand the underlying mechanisms and long term health risk of EDC exposure from the environment. We also welcome epidemiological studies that demonstrate the link between EDC exposure and its potential health risks.

Assoc. Prof. Dr. Jiangang Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Endocrine disruptor
  • Hormonal system
  • Endocrine system
  • Health outcomes
  • Low-level exposure
  • Toxicity

Published Papers (1 paper)

View options order results:
result details:
Displaying articles 1-1
Export citation of selected articles as:


Open AccessArticle
Transcriptional Analysis of Chlorella pyrenoidosa Exposed to Bisphenol A
Int. J. Environ. Res. Public Health 2019, 16(8), 1374; https://doi.org/10.3390/ijerph16081374
Received: 27 March 2019 / Revised: 9 April 2019 / Accepted: 11 April 2019 / Published: 16 April 2019
PDF Full-text (1026 KB) | HTML Full-text | XML Full-text
Bisphenol A (BPA) is the raw material of 71% of polycarbonate-based resins and 27% of epoxy-based resins which are used for coating metal-based food and beverage cans. Meanwhile, it is taken into account as a typical environmental pollutant. Hormesis may occur in algae [...] Read more.
Bisphenol A (BPA) is the raw material of 71% of polycarbonate-based resins and 27% of epoxy-based resins which are used for coating metal-based food and beverage cans. Meanwhile, it is taken into account as a typical environmental pollutant. Hormesis may occur in algae exposed to BPA. In this study, the effects of BPA on Chlorella pyrenoidosa were assessed based on growth inhibition and transcriptome analysis. We have focused on two exposure scenarios as follows: (1) exposure to a low stimulation concentration (0.1 mg.L−1, 19.35% promotion in cell density on the 3rd day); (2) exposure to a high inhibition concentration (10 mg.L−1, 64.71% inhibition in cell density on the 3rd day). Transcriptome analysis showed enrichment in nucleotide transport, single-organism transport, cellular respiration. Among them, adenosine triphosphate (ATP) synthase and Nicotinamide adenine dinucleotide (NADH) dehydrogenase were upregulated under 0.1 mg.L−1 BPA treatment. These changes enhanced the physiological and energy metabolic pathways of C. pyrenoidosa, thereby stimulating cell proliferation. At exposure to the high BPA, severe inhibited changes in the expression levels of several pathways were observed, which were related to tricarboxylic acid (TCA) cycle, glycolysis, fatty acid metabolism, oxidative phosphorylation, and photosynthesis. Therefore, BPA could negatively affect growth inhibition through the multiple energy metabolism processes. These results may result in a deeper insight into BPA-induced biphasic responses in algae, and provide vital information to assess the potential ecological risks of exposure to BPA in an aquatic ecosystem. Full article
(This article belongs to the Special Issue Endocrine Disruptor, Exposure and Potential Health Impact)

Figure 1

Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top