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Health Risk Assessment of Emerging Contaminants

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Toxicology and Public Health".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2385

Special Issue Editor


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Guest Editor
Environmental Health Evaluation and Promotion Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, 4365 Brasil Ave., Rio de Janeiro 21045-900, Brazil
Interests: biomarkers; ecotoxicology; contaminants of emerging concern; wastewater; oxidative stress; genotoxicity

Special Issue Information

Dear Colleagues,

Recent progress in analytical chemistry has made it possible to detect a growing number of emerging contaminants (ECs) in surface water, and several studies have shown their ubiquity in rivers and lakes. ECs include a wide variety of chemicals, such as microplastics, surfactants, plasticizers, nanomaterials, antibiotic-resistance genes, flame retardants, trace heavy metals, personal care products, pesticides, and endocrine-disrupting compounds. However, most ECs are not included in the list of priority pollutants, are not included in routine government monitoring programs, and their fate, behavior, and effects are often not well understood. These substances enter the aqueous environment directly following human and veterinary excretion and municipal wastewater effluents. ECs are biologically active at low concentrations and have the potential to accumulate in humans and other organisms. There are limited reports on the health risk assessment of emerging contaminants. This Special Issue of the International Journal of Environmental Research and Public Health (IJERPH) focuses on the current state of knowledge on the health risk assessment of emerging contaminants, with links between occurrence and effects on humans and other organisms. New research papers, reviews, and case reports are welcome for submission to this Special Issue. Papers dealing with new approaches to health risk assessment and the management of emerging contaminants are also welcome.

Dr. Enrico Mendes Saggioro
Guest Editor

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Keywords

  • pharmaceutical compounds
  • personal care products
  • endocrine disrupting compounds
  • microplastics
  • nanoparticles
  • antibiotic resistance genes
  • earth rare elements
  • pesticides
  • illicit drugs
  • perfluoroalkyl and polyfluoroalkyl substances

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Published Papers (1 paper)

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Research

16 pages, 3673 KiB  
Article
Ellagic Acid Prevents Particulate Matter-Induced Pulmonary Inflammation and Hyperactivity in Mice: A Pilot Study
by Sunyoung Jeong, Sungryong Bae, Eui-Cheol Shin, Jong-Hwa Lee and Jung-Heun Ha
Int. J. Environ. Res. Public Health 2023, 20(5), 4523; https://doi.org/10.3390/ijerph20054523 - 3 Mar 2023
Cited by 10 | Viewed by 2036
Abstract
The inhalation of fine particulate matter (PM) is a significant health-related environmental issue. Previously, we demonstrated that repeated PM exposure causes hyperlocomotive activity in mice, as well as inflammatory and hypoxic responses in their lungs. In this study, we evaluated the potential efficacy [...] Read more.
The inhalation of fine particulate matter (PM) is a significant health-related environmental issue. Previously, we demonstrated that repeated PM exposure causes hyperlocomotive activity in mice, as well as inflammatory and hypoxic responses in their lungs. In this study, we evaluated the potential efficacy of ellagic acid (EA), a natural polyphenolic compound, against PM-induced pulmonary and behavioral abnormalities in mice. Four treatment groups were assigned in this study (n = 8): control (CON), particulate-matter-instilled (PMI), low-dose EA with PMI (EL + PMI), and high-dose EA with PMI (EH + PMI). EA (20 and 100 mg/kg body weight for low dose and high dose, respectively) was orally administered for 14 days in C57BL/6 mice, and after the eighth day, PM (5 mg/kg) was intratracheally instilled for 7 consecutive days. PM exposure induced inflammatory cell infiltration in the lungs following EA pretreatment. Moreover, PM exposure induced inflammatory protein expression in the bronchoalveolar lavage fluid and the expression of inflammatory (tumor necrosis factor alpha (Tnfα), interleukin (Il)-1b, and Il-6) and hypoxic (vascular endothelial growth factor alpha (Vegfα), ankyrin repeat domain 37 (Ankrd37)) response genes. However, EA pretreatment markedly prevented the induction of expression of inflammatory and hypoxic response genes in the lungs. Furthermore, PM exposure significantly triggered hyperactivity by increasing the total moving distance with an increase in moving speed in the open field test. On the contrary, EA pretreatment significantly prevented PM-induced hyperactivity. In conclusion, dietary intervention with EA may be a potential strategy to prevent PM-induced pathology and activity. Full article
(This article belongs to the Special Issue Health Risk Assessment of Emerging Contaminants)
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