Human Microphysiology Systems
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601).
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 198
Special Issue Editors
Interests: microphysiology systems development; blood-brain barrier; cellular and molecular neuroscience
Special Issue Information
Dear Colleagues,
While there is no denying the great strides that have been made in biomedical research from 2D cell culture on plastic, we are rapidly reaching the point where the low-hanging fruit has been picked and new technologies are needed to make the next leap in advancements.
Current standard cell culture often has a single cell type grown in isolation and fed in an ocean of media whose sugar, salt, and growth factor levels are high enough to be toxic if found in human blood. If we want a lower fail rate in efficacy trials for new drugs and treatments, new ways of engineering our cellular models must be created so that our test base more closely mimics the human condition.
These new systems will need to have not only mammalian cells but human cells grown in three dimensions, as well as cells grown out of isolation but with the relevant tissue-specific cells around them forming a micro organ. These new systems will need constant perfusion so that media volume and composition can finally shift to more physiologically relevant—rather than super-physiological—levels. Microphysiology systems are uniquely poised to fulfill this research need and to expand the cell biologist’s tool kit.
Papers developing new human microphysiology systems or new methods of evaluating them are invited for this Special Issue.
Dr. Jacquelyn Ann Brown
Dr. Nathan Sorensen
Guest Editors
Manuscript Submission Information
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Keywords
- microphysiology systems
- organs on a chip
- tissue-engineered
- organ constructs
- drug discovery and development
- drug safety and toxicity
- drug–organ interactions
- systems biology
- quantitative systems pharmacology
- induced pluripotent stem cells
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