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Dermatologic Therapy Research and Public Health
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Dermatologic Therapy Research and Public Health

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 42694

Special Issue Editors

Prof. Dr. Agnieszka Owczarczyk-Saczonek

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Guest Editor
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland
Interests: psoriasis; inflammatory immune-mediated inflammatory disease; metabolic diseases
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Waldemar Placek

E-Mail Website
Guest Editor
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology The University of Warmia and Mazury, Al. Wojska Polskiego 30, 10-229 Olsztyn, Poland
Interests: psoriasis; non-melanoma skin cancer; melanoma; dermatosurgery
Prof. Dr. Magdalena Krajewska-Włodarczyk

E-Mail Website
Guest Editor
Department of Rheumatology, The University of Warmia and Mazury, Al. Wojska Polskiego 30, 10-229 Olsztyn, Poland
Interests: rheumatic diseases; psoriatic arthritis; ultrasound of the nails; biologic therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For this Special Issue, we invite researchers to submit high-quality original papers or systematic reviews focusing on the practical aspects of the management of autoinflammatory and autoimmunological dermatological diseases.

Skin diseases are chronic, affecting many aspects of a patient’s life, resulting in a significant reduction in the quality of life and even depression. New therapeutic options are sought, because standard treatment often does not meet the expectations of the doctor and the patient. Here, we present new therapeutic treatment options.

This Special Issue focuses on new therapeutic options for treatment and other possibilities of well-known medications.

Prof. Dr. Agnieszka Owczarczyk-Saczonek
Prof. Dr. Waldemar Placek
Dr. Magdalena Krajewska-Włodarczyk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acne
  • psoriasis
  • lichen sclerosus
  • morphea
  • vitiligo
  • tetracyclines
  • isotretinoin
  • laser CO2 fraxel

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Published Papers (7 papers)

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Research

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12 pages, 1623 KiB  
Article
The Effect of the Long-Term Calcipotriol/Betamethasone Dipropionate Local Therapy on Tissue Resident Memory Cells Markers in Psoriatic Eruptions
by Marta Kasprowicz-Furmańczyk, Joanna Czerwińska, Waldemar Placek and Agnieszka Owczarczyk-Saczonek
Int. J. Environ. Res. Public Health 2022, 19(14), 8345; https://doi.org/10.3390/ijerph19148345 - 8 Jul 2022
Cited by 5 | Viewed by 2956
Abstract
Background: The natural course of psoriasis is characterized by the long-term persistence of lesions and a predilection for relapse in the same area. It is caused by the inherence of TRM (tissue resident memory T cells) in apparently healthy skin. These cells are [...] Read more.
Background: The natural course of psoriasis is characterized by the long-term persistence of lesions and a predilection for relapse in the same area. It is caused by the inherence of TRM (tissue resident memory T cells) in apparently healthy skin. These cells are able to initiate an inflammatory cascade and induce relapse of the disease. These cells are characterized by high resistance to damaging factors and apoptosis, which determines their longevity. Aim: The aim of our study was to evaluate the presence of TRM in psoriatic plaques before, during and after 12 weeks of therapy in patients treated with topical calcipotriol and betamethasone dipropionate (Cal/BD) foam. Methods: TRM markers (CD4, CD8, CD103, CD69, CD49, CXCR6) and tissue expression of cytokines (IL-17A, IL-22) in the lesional psoriatic skin from 10 patients compared to 10 healthy skin samples were estimated by immunohistochemistry. Biopsy samples from the area of the same psoriatic plaque were collected three times: before the initiation of therapy, 4 and 12 weeks after its initiation. Results: The presence of TRM markers in the epidermis and dermis of psoriatic lesions was significantly higher when compared to the skin of control group patients. A reduction in the expression of the characteristic TRM markers (CD8, CD4, CD103, CD69, CXCR6, IL-17A and IL-22) was observed in the epidermis on week 12 of therapy, while a depletion in the expression of TRM in the dermis was demonstrated only in CD4 and IL-22. Conclusions: Topical treatment with Cal/BD foam significantly decreased the expression of TRM markers mainly in the epidermis, and to a lesser extent in the dermis, during the 12-week observation period. It probably results from a worse penetration of the drug into the dermis and the effect of the preparation mainly on the epidermis. The persistence of a high expression of TRM markers in the dermis may result in the rapid recurrence of lesions after discontinuation of topical treatment. Full article
(This article belongs to the Special Issue Dermatologic Therapy Research and Public Health)
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12 pages, 2583 KiB  
Article
Assessment of the Tissue Resident Memory Cells in Lesional Skin of Patients with Psoriasis and in Healthy Skin of Healthy Volunteers
by Marta Kasprowicz-Furmańczyk, Joanna Czerwińska, Waldemar Placek and Agnieszka Owczarczyk-Saczonek
Int. J. Environ. Res. Public Health 2021, 18(21), 11251; https://doi.org/10.3390/ijerph182111251 - 26 Oct 2021
Cited by 14 | Viewed by 2717
Abstract
Background: In the course of plaque psoriasis, tissue resident memory cells (TRM) are responsible for the phenomenon of “immune memory” of lesions, i.e., the appearance of recurrences of lesions in the same location, as well as Koebner phenomenon. We present results determining the [...] Read more.
Background: In the course of plaque psoriasis, tissue resident memory cells (TRM) are responsible for the phenomenon of “immune memory” of lesions, i.e., the appearance of recurrences of lesions in the same location, as well as Koebner phenomenon. We present results determining the location and amount of TRM in psoriatic lesions in patients suffering from plaque psoriasis, as well as an analysis of the relationship between TRM markers expression and the duration and severity of the disease. Methods: TRM markers (CD4, CD8, CD103, CD69, CD49, CXCR6) and tissue expression of cytokines (IL-17, IL-22) in the lesional psoriatic skin of 32 patients compared with 10 healthy skin samples were evaluated by immunohistochemistry. Results: The presence of TRM markers in both the epidermis and skin with psoriatic eruptions was demonstrated in much higher amounts compared with the skin of healthy volunteers. A significant positive relationship was demonstrated between the expression of TRM markers in patients with plaque psoriasis and the duration of skin lesions. There was no relationship between the amount of TRM and the severity of plaque psoriasis. Conclusions: A thorough understanding of the mechanisms responsible for the development and relapse of plaque psoriasis may contribute to the implementation of more effective therapies. Full article
(This article belongs to the Special Issue Dermatologic Therapy Research and Public Health)
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Review

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13 pages, 374 KiB  
Review
Tetracyclines—An Important Therapeutic Tool for Dermatologists
by Malgorzata Orylska-Ratynska, Waldemar Placek and Agnieszka Owczarczyk-Saczonek
Int. J. Environ. Res. Public Health 2022, 19(12), 7246; https://doi.org/10.3390/ijerph19127246 - 13 Jun 2022
Cited by 25 | Viewed by 3974
Abstract
Tetracyclines are a group of antibiotics whose first representative was discovered over 70 years ago. Since then, they have been of great interest in dermatology. In addition to their antibacterial activity, they are able to inhibit metalloproteinases and exhibit anti-inflammatory, anti-apoptotic and antioxidant [...] Read more.
Tetracyclines are a group of antibiotics whose first representative was discovered over 70 years ago. Since then, they have been of great interest in dermatology. In addition to their antibacterial activity, they are able to inhibit metalloproteinases and exhibit anti-inflammatory, anti-apoptotic and antioxidant effects. The side effects have been thoroughly studied over the years, the most characteristic and important ones in daily dermatological practice being: phototoxicity, hyperpigmentation, onycholysis, photoonycholysis, induced lupus erythematosus, and idiopathic intracranial hypertension. In this article, we summarize the use of tetracyclines in infectious diseases and inflammatory dermatoses, and further discuss the instances where the efficacy and safety of tetracyclines have been highlighted over the past few years. Full article
(This article belongs to the Special Issue Dermatologic Therapy Research and Public Health)
13 pages, 2841 KiB  
Review
Usefulness of Ultrasound Examination in the Assessment of the Nail Apparatus in Psoriasis
by Magdalena Krajewska-Włodarczyk and Agnieszka Owczarczyk-Saczonek
Int. J. Environ. Res. Public Health 2022, 19(9), 5611; https://doi.org/10.3390/ijerph19095611 - 5 May 2022
Cited by 13 | Viewed by 7634
Abstract
The assessment of psoriatic nail changes in everyday practice is based exclusively on clinical symptoms that do not reflect the entire disease process in the nail apparatus. The use of imaging methods, especially widely available and inexpensive ultrasonography, creates the possibility of additional [...] Read more.
The assessment of psoriatic nail changes in everyday practice is based exclusively on clinical symptoms that do not reflect the entire disease process in the nail apparatus. The use of imaging methods, especially widely available and inexpensive ultrasonography, creates the possibility of additional revealing and assessing grayscale of morphological changes of the ventral nail plate, nail bed, and matrix, as well as the attachment of the finger extensor tendon to the distal phalanx. What is more, it enables the assessment of inflammation severity in the power Doppler technique. A qualitative classification of nail plate morphological changes corresponding to the severity of psoriatic nail changes has been developed so far and attempts are being made to develop a quantitative method to assess not only the presence of changes but also the severity of inflammation. Nail ultrasonography is not commonly performed, although published studies indicate the possible use of this technique in the assessment of psoriatic changes in nail structures. It can be particularly useful in subclinical changes imaging, preceding clinical manifestation of psoriatic nail changes, enthesopathy: subclinical and in the course of psoriatic arthritis, as well as in the assessment of treatment efficacy. This review article aims to summaries the research on ultrasonography of the nail apparatus which has been carried out so far, taking into account its applicability in clinical practice. Full article
(This article belongs to the Special Issue Dermatologic Therapy Research and Public Health)
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21 pages, 704 KiB  
Review
Surgical Treatment of Vitiligo
by Alicja Frączek, Marta Kasprowicz-Furmańczyk, Waldemar Placek and Agnieszka Owczarczyk-Saczonek
Int. J. Environ. Res. Public Health 2022, 19(8), 4812; https://doi.org/10.3390/ijerph19084812 - 15 Apr 2022
Cited by 19 | Viewed by 8406
Abstract
Vitiligo is described as a dermatological condition characterized by pigmentation disorders in both the skin and mucous membranes. Clinically, this disease is characterized by the presence of well-defined white areas of various shapes and sizes, which are a manifestation of a reduced number [...] Read more.
Vitiligo is described as a dermatological condition characterized by pigmentation disorders in both the skin and mucous membranes. Clinically, this disease is characterized by the presence of well-defined white areas of various shapes and sizes, which are a manifestation of a reduced number of melanocytes. Due to the fact that vitiligo can be a significant cosmetic problem for patients, a number of methods are currently available to help fight for a better skin appearance. If all the available non-invasive procedures turn out to be ineffective, surgery can help, which is a very good alternative in the case of difficult-to-treat but stable changes. Both the development of new techniques and modifications to the already available treatment of cell and tissue transplantation give hope to numerous patients around the world. The effectiveness of a particular method is determined by its appropriate selection depending on the lesions undergoing therapy. Each form of surgical intervention has its advantages and disadvantages, which, along with the location or size of the treated hypopigmentation area, should be analyzed by a doctor and discussed with their patient. This article is an overview of the currently available methods of surgical treatment of vitiligo and a comparison of their pros and cons. Full article
(This article belongs to the Special Issue Dermatologic Therapy Research and Public Health)
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Other

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11 pages, 3954 KiB  
Case Report
Fractional Ablative Carbon Dioxide Lasers for the Treatment of Morphea: A Case Series and Literature Review
by Paulina Klimek, Waldemar Placek and Agnieszka Owczarczyk-Saczonek
Int. J. Environ. Res. Public Health 2022, 19(13), 8133; https://doi.org/10.3390/ijerph19138133 - 2 Jul 2022
Cited by 5 | Viewed by 5715
Abstract
Morphea is an inflammatory, immune-mediated disease of unknown aetiology. It is characterised by excessive collagen deposition, which leads to the hardening of the dermis and subcutaneous tissues. The disease is associated with cosmetic and functional impairment, which can affect the patients’ quality of [...] Read more.
Morphea is an inflammatory, immune-mediated disease of unknown aetiology. It is characterised by excessive collagen deposition, which leads to the hardening of the dermis and subcutaneous tissues. The disease is associated with cosmetic and functional impairment, which can affect the patients’ quality of life. Fractional ablative lasers (FALs) are currently used for the treatment of many skin diseases that are connected to tissue fibrosis due to the low risk of side effects and their great effectiveness. This study aimed to improve the aesthetic defects that are caused by morphea lesions and assess the efficacy and safety of FAL use in this indication. We also reviewed the literature on the subject. We present four women with biopsy-proven morphea, manifesting as hyperpigmented plaques and patches. One of the patients additionally had morphea-related knee joint contracture. Four fractional CO2 laser sessions, separated by one-month intervals, were performed and produced significant improvements in dyspigmentation and induration. An improved elasticity and a decrease in dermal thickness were also obtained, as proven by measurements using DermaLab Combo. No severe adverse effects occurred. Based on these cases presented by the authors, fractional CO2 lasers appear to be an effective, well-tolerated, and safe therapeutic option for patients suffering from morphea. Full article
(This article belongs to the Special Issue Dermatologic Therapy Research and Public Health)
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21 pages, 764 KiB  
Systematic Review
Adverse Events in Isotretinoin Therapy: A Single-Arm Meta-Analysis
by Jan Kapała, Julia Lewandowska, Waldemar Placek and Agnieszka Owczarczyk-Saczonek
Int. J. Environ. Res. Public Health 2022, 19(11), 6463; https://doi.org/10.3390/ijerph19116463 - 26 May 2022
Cited by 19 | Viewed by 9216
Abstract
Isotretinoin (ISO) is an oral prescription-only retinoid, well known for its acne-treating effect. However, it affects a substantial number of human cell types, causing a broad spectrum of adverse effects. The purpose of this study is to establish the isotretinoin therapy adverse events [...] Read more.
Isotretinoin (ISO) is an oral prescription-only retinoid, well known for its acne-treating effect. However, it affects a substantial number of human cell types, causing a broad spectrum of adverse effects. The purpose of this study is to establish the isotretinoin therapy adverse events among human clinical trials and their prevalence. Two authors (J.K., J.L.) systematically performed the literature review and assessment from December 2021–February 2022. Three databases (PubMed, ClinicalTrials, and Cochrane Library) were searched using the following terms: “isotretinoin acne vulgaris” for published studies in English from 1980–2021. Finally, 25 randomized controlled clinical trials (RCTs) and five open-label clinical trials provided 3274 acne vulgaris suffering patients. Isotretinoin therapy affects almost all of the systems in the human body, causing numerous adverse events. However, they mainly concern mild mucocutaneous conditions (severe cases are rare) and represent individual responses to a drug. In addition, all adverse events are reversible and can be avoided by specific preparations. Full article
(This article belongs to the Special Issue Dermatologic Therapy Research and Public Health)
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