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Cancer Research and Health
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Cancer Research and Health

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".

Deadline for manuscript submissions: closed (30 June 2022)

Special Issue Editor

Prof. Dr. El-Sayed Abd El-Aziz

E-Mail Website
Guest Editor
Department of Pharmacology, Pharmacology, Zagazig University, 44519 Zagazig, Egypt
Interests: cancer biology; natural plant activities; oxidative stress; molecular biology; diabetes mellitus; hepatoprotective; testicular protection; metal drug complexes; plant extracts; MTT assay; cell line experiments; wound-healing cellular assay; cell migration assay; renal functions; hepatorenal functions; chemical characterizations; chitosan; flavonoid activities; phenolic activities; zinc oxide nanoparticle activities; COVID-19; antibacterial activities; antiviral activities; DPPH activity; natural extracts; HPLC; UHPLC-UV; FTIR; spectroscopic analysis; zeta potential; surface area; flow cytometry; quantitative assay; qualitative assay; cytotoxicity assay; apoptosis; natural residues; solid waste; industrial waste; aging; neuroprotective agents; active compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent experimental developments in nanoformula of different biomedical activity of  natural plant extracts and efficacy of active compounds are among the most highly-exploited research systems in the field of cancer biology. Driven by the current state of knowledge of biomedical efficiency of the drugs and some natural agents, the need to maintain structural material integrity and reliability assets under harsh environments, and a renewed impetus towards durability of new nanostructured against several diseases like cancer and metabolic diseases like Diabetes , have seen a huge demand on experimental, theoretical and modelling activities.

Studying the hepatoprotective , neuroprotective , testicular protective activities of the natural extracts and a lot of active compounds against different disorders and aging progression and make high benefits of these compounds by complete chemical characterization and spectroscopic analysis. Beside testing the wound healing assay of some compounds and testing the activities of antibiotic metal drug complexes and flavonoid metal drug complexes against environmental infections.

This scope of this Special Issue will serve as a forum for papers in the following concepts:

  • Experimental research, knowledge and new ideas about protective effects of natural extracts against different diseases including cancer and diabetes.
  • Recent developments in activities of natural products and active compounds in treatment of diseases.
  • Anti-cancer activities of some natural plant extracts and Nano-formula.
  • Experimental and processing high-performance cromatography with exposure to high temperatures, high stress, and other extreme environmental applications.
  • The latest development of anticancer and anti-diabetic agents from natural extracts and different chemical agents.
  • Computer modeling, simulation to predict nanoparticles' properties, performance  in service environments.
  • Metal drug and natural extract complexes  with antibiotics and  falvonoids' agents with chemical characterization and spectroscopic analysis against infections.

Prof. Dr. El-Sayed Abd El-Aziz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Anticancer drugs
  • Biomedical activities of natural extracts
  • Nanoparticle activities
  • Anticancer agents activities
  • Protective effects of active compounds
  • Spectroscopic characterization and analysis of metal complexes

Published Papers (1 paper)

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Research

19 pages, 3454 KiB  
Article
In Situ Neutral System Synthesis, Spectroscopic, and Biological Interpretations of Magnesium(II), Calcium(II), Chromium(III), Zinc(II), Copper(II) and Selenium(IV) Sitagliptin Complexes
by Samy M. El-Megharbel, Moamen S. Refat, Fawziah A. Al-Salmi and Reham Z. Hamza
Int. J. Environ. Res. Public Health 2021, 18(15), 8030; https://doi.org/10.3390/ijerph18158030 - 29 Jul 2021
Cited by 12 | Viewed by 2134
Abstract
Magnesium(II), calcium(II), chromium(III), zinc(II), copper(II), and selenium(IV) sitagliptin (STG) complexes—with the general formulas [Mg(STG)2(Cl)2]·6H2O, [Ca(STG)2(Cl)2], [Cr(STG)2(Cl)2]Cl.6H2O, [Zn(STG)2(Cl)2], [Cu(STG)2(Cl)2]·2H2 [...] Read more.
Magnesium(II), calcium(II), chromium(III), zinc(II), copper(II), and selenium(IV) sitagliptin (STG) complexes—with the general formulas [Mg(STG)2(Cl)2]·6H2O, [Ca(STG)2(Cl)2], [Cr(STG)2(Cl)2]Cl.6H2O, [Zn(STG)2(Cl)2], [Cu(STG)2(Cl)2]·2H2O, and [Se(STG)2(Cl)2]Cl2, respectively—were designed and synthesized by the chemical reactions between metal(II, III, and IV) chloride salts with an STG ligand in situ methanol solvent in a 1:2 stoichiometric ratio (metal:ligand). Tentative structures of the complexes were proposed based on elemental analysis, molar conductance, magnetic moments, thermogravimetric analysis, and spectral (infrared, electronic, and 1H NMR) data. The particle size and morphological investigation were checked on the bases of scanning electron microscopy, transmission electron microscopy, and X-ray powder diffraction analyses. All the Mg2+, Ca2+, Cr3+, Zn2+, Cu2+, and Se4+ complexes were found to be six-coordinated, wherein the STG ligands act as bidentate chelating agents. This study demonstrates that pancreatic tissues are affected by the induction of experimental diabetes mellitus and clarifies the potential of the synthesized STG complexes, which was found to more significantly improve insulin secretion and the pancreatic and glycometabolic complications of diabetic rats than STG alone. Full article
(This article belongs to the Special Issue Cancer Research and Health)
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