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Article

In Situ Neutral System Synthesis, Spectroscopic, and Biological Interpretations of Magnesium(II), Calcium(II), Chromium(III), Zinc(II), Copper(II) and Selenium(IV) Sitagliptin Complexes

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Department of Chemistry, College of Science, Zagazig University, Zagazig 44519, Egypt
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Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
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Department of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
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Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(15), 8030; https://doi.org/10.3390/ijerph18158030
Received: 28 June 2021 / Revised: 18 July 2021 / Accepted: 21 July 2021 / Published: 29 July 2021
(This article belongs to the Special Issue Cancer Research and Health)
Magnesium(II), calcium(II), chromium(III), zinc(II), copper(II), and selenium(IV) sitagliptin (STG) complexes—with the general formulas [Mg(STG)2(Cl)2]·6H2O, [Ca(STG)2(Cl)2], [Cr(STG)2(Cl)2]Cl.6H2O, [Zn(STG)2(Cl)2], [Cu(STG)2(Cl)2]·2H2O, and [Se(STG)2(Cl)2]Cl2, respectively—were designed and synthesized by the chemical reactions between metal(II, III, and IV) chloride salts with an STG ligand in situ methanol solvent in a 1:2 stoichiometric ratio (metal:ligand). Tentative structures of the complexes were proposed based on elemental analysis, molar conductance, magnetic moments, thermogravimetric analysis, and spectral (infrared, electronic, and 1H NMR) data. The particle size and morphological investigation were checked on the bases of scanning electron microscopy, transmission electron microscopy, and X-ray powder diffraction analyses. All the Mg2+, Ca2+, Cr3+, Zn2+, Cu2+, and Se4+ complexes were found to be six-coordinated, wherein the STG ligands act as bidentate chelating agents. This study demonstrates that pancreatic tissues are affected by the induction of experimental diabetes mellitus and clarifies the potential of the synthesized STG complexes, which was found to more significantly improve insulin secretion and the pancreatic and glycometabolic complications of diabetic rats than STG alone. View Full-Text
Keywords: sitagliptin; complexes; spectroscopic; morphology; STZ; diabetes sitagliptin; complexes; spectroscopic; morphology; STZ; diabetes
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MDPI and ACS Style

El-Megharbel, S.M.; Refat, M.S.; Al-Salmi, F.A.; Hamza, R.Z. In Situ Neutral System Synthesis, Spectroscopic, and Biological Interpretations of Magnesium(II), Calcium(II), Chromium(III), Zinc(II), Copper(II) and Selenium(IV) Sitagliptin Complexes. Int. J. Environ. Res. Public Health 2021, 18, 8030. https://doi.org/10.3390/ijerph18158030

AMA Style

El-Megharbel SM, Refat MS, Al-Salmi FA, Hamza RZ. In Situ Neutral System Synthesis, Spectroscopic, and Biological Interpretations of Magnesium(II), Calcium(II), Chromium(III), Zinc(II), Copper(II) and Selenium(IV) Sitagliptin Complexes. International Journal of Environmental Research and Public Health. 2021; 18(15):8030. https://doi.org/10.3390/ijerph18158030

Chicago/Turabian Style

El-Megharbel, Samy M., Moamen S. Refat, Fawziah A. Al-Salmi, and Reham Z. Hamza. 2021. "In Situ Neutral System Synthesis, Spectroscopic, and Biological Interpretations of Magnesium(II), Calcium(II), Chromium(III), Zinc(II), Copper(II) and Selenium(IV) Sitagliptin Complexes" International Journal of Environmental Research and Public Health 18, no. 15: 8030. https://doi.org/10.3390/ijerph18158030

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