Molecular Determinants of Cardiac Arrhythmias

Dear Colleagues,

Cardiac arrhythmias constitute one of the major burdens in medical practice. Atrial fibrillation is the most frequent arrhythmia, with an estimated prevalance of 2–4% in the general population increasing to >10% in the elderly. Sudden cardiac death (SCD), mostly due to ventricular fibrillation, represents a major worldwide public health problem, accounting for 15–20 % of all deaths. Other arrhythmias such as Brugada, long-QT, and short-QT, although having a lower prevalence, similarly provide enormous concerns in terms of societal distress, public health, and medical treatment. Over the last decades, our understanding of the cellular, molecular, and genetics bases of arrhythmogenesis has exponentially increased, including the identification of genetic hallmarks and the identification of electrophysiological and electromechanical bases. Recently, novel insights have been gained via the identification of novel regulatory mechanisms contributing to the onset and course of cardiac arrhythmias, including diverse epigenetic mechanisms. In this Special Issue, we aim to gather state-of-the-art insights into the cellular, molecular, genetic, and epigenetic mechanisms involved in cardiac arrhythmias.

Prof. Dr. Diego Franco Jaime
Guest Editor

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