Prevention, Diagnosis, Treatment and Healthcare for the People with Neurodegenerative Diseases: Second Edition

A Special Issue of Healthcare (ISSN 2227-9032).

Deadline for manuscript submissions: 30 July 2027 | Viewed by 2088

Editor


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Guest Editor
1. Division of Neurology, Department of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada
2. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, 14186 Stockholm, Sweden
Interests: neuroepidemiology; clinical neuroscience; neurodegenerative disorders; neuroimaging; Parkinson’s disease; neuro-prevention
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Special Issue Information

Dear Colleagues,

Neurodegenerative disorders are a heterogenous group of neurologic entities with various pathogenesis consisting of proteinopathies (e.g., Parkinson’s disease, Alzheimer’s disease, other dementias), motor neuron diseases (e.g., amyotrophic lateral sclerosis (ALS)), autoimmune-related (e.g., multiple sclerosis), or genetic disorders (e.g., Huntington’s disease, spinocerebellar ataxia (SCA)). Neurodegenerative diseases are progressive, with debilitating consequences affecting motor, cognitive, and behavioural performances. The burden of these diseases, particularly age-related proteinopathies (e.g., Parkinson’s disease and Alzheimer’s disease), is steadily increasing in most countries, mainly due to population ageing and longevity. Due to multi-domain involvement, chronicity and progressive course, caring for people with neurodegenerative diseases is highly complex. Even though many of the neurodegenerative diseases (i.e., Parkinson’s disease and Alzheimer’s disease) are preceded by a long prodromal stage of up to 1–2 decades prior to the presence of debilitating motor or cognitive symptoms, there is currently no neuroprotective agent that can reverse or halt their pathogenesis. Furthermore, disease-modifying treatments only exist for certain conditions, such as multiple sclerosis.

This Special Issue seeks original research articles and reviews that address different aspects of neurodegenerative diseases, namely prevention, diagnosis, symptomatic and/or disease-modifying treatments, as well as multidisciplinary management and care plans. Papers tackling the themes of prevention, novel diagnostic biomarkers, treatments, and the latest advances in the management of neurodegenerative diseases using a multidisciplinary approach are of particular interest.

This Special Issue aims to provide an updated panorama of the current state-of-the-art and emerging trends in healthcare to reduce the global burden of neurodegenerative diseases.

Dr. Seyed Mohammad Fereshtehnejad
Guest Editor

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Keywords

  • healthcare
  • disease modifying treatment
  • prevention
  • neurorehabilitation
  • neuroimaging
  • neurodegenerative diseases
  • Alzheimer’s disease and other dementias
  • Parkinson’s disease
  • motor neuron disease
  • multiple system atrophy
  • progressive supranuclear palsy
  • multiple sclerosis
  • Huntington’s disease

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Published Papers (1 paper)

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20 pages, 1363 KB  
Systematic Review
Home-Based Digital Healthcare Interventions for Dementia: A Systematic Review of Patient and Family Caregiver Outcomes
by Mohammed Nasser Albarqi
Healthcare 2026, 14(7), 854; https://doi.org/10.3390/healthcare14070854 - 27 Mar 2026
Cited by 1 | Viewed by 1716
Abstract
Background: Home-based digital healthcare interventions are increasingly used to support people living with dementia (PLWD) and their family caregivers. However, evidence regarding their effectiveness across patient and caregiver outcomes remains heterogeneous. Methods: This systematic review followed PRISMA 2020 guidelines and was prospectively registered [...] Read more.
Background: Home-based digital healthcare interventions are increasingly used to support people living with dementia (PLWD) and their family caregivers. However, evidence regarding their effectiveness across patient and caregiver outcomes remains heterogeneous. Methods: This systematic review followed PRISMA 2020 guidelines and was prospectively registered in PROSPERO (CRD420261302166). Six databases (PubMed, Embase, CINAHL, PsycINFO, Web of Science, and Scopus) were searched from January 2000 to October 2025. Randomized and quasi-experimental quantitative studies evaluating home-based or remotely delivered digital interventions for PLWD and/or informal caregivers were included. Risk of bias was assessed using RoB 2 and ROBINS-I. Due to heterogeneity, findings were synthesized narratively. Results: Fourteen studies met the inclusion criteria. Interventions included web-based psychoeducation, telecoaching, digital cognitive training, assistive technologies, and multicomponent programs. Caregiver outcomes demonstrated the most consistent benefits, including reduced burden and stress, improved self-efficacy, and improved sleep efficiency in technology-supported trials. For PLWD, small-to-moderate improvements were observed in global cognition and selected neuropsychiatric symptoms, particularly in interactive and personalized programs. Multicomponent interventions combining caregiver education with patient activation and professional feedback showed more durable effects. Conclusions: Home-based digital interventions appear feasible and beneficial, particularly for caregiver outcomes. Future large-scale trials with longer follow-up and standardized outcome measures are needed to confirm durability, equity, and cost-effectiveness. Full article
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